Rat Insulin Competitive Standard (大鼠胰岛素竞争法 标准品)

INS 分子靶点信息概述

• 分子名：INS, insulin
• 基因家族：Neuropeptides
• 曾用名：IDDM2; IDDM1
• 全称：insulin-dependent diabetes mellitus 2

INS 分子靶点综述

胰岛素是一种由胰岛β细胞和一些硬骨鱼布氏体分泌产生的肽类激素。它通过促进脂肪、肝脏和骨骼肌细胞吸收血液中的葡萄糖，从而对糖类、脂肪和蛋白质代谢起重要作用。这些组织吸收的葡萄糖转化为糖原或者脂肪(甘油三酯)， 而肝脏是个例外，其吸收的葡萄糖可以转化为糖原和脂肪。肝脏中的葡萄糖产量受血液中高浓度胰岛素强烈抑制。血液中胰岛素浓度高时，它就是一种同化激素，可促进血液中的小分子转化为细胞内的大分子。血液中胰岛素浓度低时，它通过促进广泛的分解代谢而产生相反的效果。当胰岛β细胞被自身免疫过程破坏，胰岛素就不再合成或者分泌到血液中，进而导致 1 型糖尿病。遗传易感性和环境因素的综合影响会导致胰岛素抵抗，这就是 2 型糖尿病。另外，胰岛β细胞产生过量的胰岛素或反应性低血糖都与胰岛素瘤有关。

大鼠 Rat Ins2 分子靶点信息

• 分子名：Ins2, insulin 2
• 别称：
  • C-peptide
  • CP-II
  • insulin-2
  • LOC102549619
  • uncharacterized LOC102549619
• 基因序列：NCBI_Gene: 24506
• 蛋白序列：UniProtKB: P01323

大鼠 Rat Ins2 靶点分子功能（预测）

Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of catabolic process; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Located in extracellular space. Colocalizes with secretory granule. Used to study hypertension. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin).