Human IL-8 High Sensitivity Standard (人白细胞介素8 高敏 标准品)

CXCL8 分子靶点信息概述

• 分子名：CXCL8, C-X-C motif chemokine ligand 8
• 基因家族：Chemokine ligands; Interleukins
• 别名：SCYB8; LUCT; LECT; MDNCF; TSG-1; IL-8; NAP-1; 3-10C; MONAP; AMCF-I; LYNAP; NAF; b-ENAP; GCP-1; K60; GCP1; NAP1
• 曾用名：IL8
• 全称：neutrophil-activating peptide 1; granulocyte chemotactic protein 1; monocyte-derived neutrophil chemotactic factor; lung giant cell carcinoma-derived chemotactic protein; tumor necrosis factor-induced gene 1; monocyte-derived neutrophil-activating peptide; lymphocyte derived neutrophil activating peptide; beta endothelial cell-derived neutrophil activating peptide; alveolar macrophage chemotactic factor I; interleukin 8; chemokine (C-X-C motif) ligand 8

CXCL8 分子靶点综述

白细胞介素8(IL-8)是由巨噬细胞和其它类型细胞如上皮细胞、气道平滑肌细胞和内皮细胞产生的趋化因子，在人类中，由IL8基因编码。IL-8可有效促进血管生成，在细支气管炎的发病机制中起重要作用。IL-8可通过对中性粒细胞的召集和脱颗粒来实现对炎症反应的调节，可作为结肠癌细胞株的自分泌生长因子来作用于结肠直肠癌。高水平的IL-8可减少精神分裂症患者抗精神病药的阳性反应。另外，IL-8与肥胖和囊性纤维化的发病机制也相关。

人 Human CXCL8 分子靶点信息

• 分子名：CXCL8, C-X-C motif chemokine ligand 8
• 别称：
  • alveolar macrophage chemotactic factor I
  • beta endothelial cell-derived neutrophil activating peptide
  • beta-thromboglobulin-like protein
  • C-X-C motif chemokine 8
  • chemokine (C-X-C motif) ligand 8
  • emoctakin
  • GCP-1
  • GCP1
  • granulocyte chemotactic protein 1
  • IL8
  • interleukin 8
  • interleukin-8
  • LECT
  • LUCT
  • lung giant cell carcinoma-derived chemotactic protein
  • lymphocyte derived neutrophil activating peptide
  • lymphocyte-derived neutrophil-activating factor
  • LYNAP
  • MDNCF
  • MONAP
  • monocyte-derived neutrophil chemotactic factor
  • monocyte-derived neutrophil-activating peptide
  • NAF
  • NAP-1
  • NAP1
  • neutrophil-activating peptide 1
  • SCYB8
  • small inducible cytokine subfamily B, member 8
  • T cell chemotactic factor
  • T-cell chemotactic factor
  • tumor necrosis factor-induced gene 1
• 基因序列：NCBI_Gene: 3576
• 蛋白序列：UniProtKB: P10145

人 Human CXCL8靶点分子功能（预测）

Enables chemokine activity and interleukin-8 receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; induction of positive chemotaxis; and neutrophil chemotaxis. Acts upstream of or within negative regulation of cell adhesion molecule production; positive regulation of cellular biosynthetic process; and regulation of gene expression. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including autoimmune uveitis; bacterial gastritis; gastrointestinal system cancer (multiple); trachoma; and urinary tract infection. Biomarker of several diseases, including chikungunya; cholestasis (multiple); cystic fibrosis; liver disease (multiple); and tuberculosis (multiple).