Rat IL-1α Standard (大鼠白细胞介素1 (IL-1) 标准品)

IL1A 分子靶点信息概述

• 分子名：IL1A, interleukin 1 alpha
• 基因家族：Interleukins
• 别名：IL1F1; IL-1A; IL1-ALPHA
• 曾用名：IL1
• 全称：preinterleukin 1 alpha; hematopoietin-1; pro-interleukin-1-alpha

IL1A 分子靶点综述

白细胞介素1(IL-1)是17kDa的胞外多肽，分为IL-1α和IL-1β两种蛋白。IL-1α是一种多效性细胞因子，在人类中由IL1A基因编码。IL-1α主要由活化的巨噬细胞、中性粒细胞、上皮细胞和内皮细胞产生。它具有代谢、生理、造血活性，在调节免疫应答中起到核心作用。IL-1α可与HAX1、NDN相互作用，但是与TNF之间的协同作用是临床上最相关的。IL-1α和TNF都是急性期细胞因子，具有促发热和发炎作用。人们目前正在评估IL-1α是否可作为临床试验中一个潜在治疗肿瘤的标志物。阻断IL-1α活性具有潜在治疗皮肤病的作用，例如痤疮。

大鼠 Rat Il1a 分子靶点信息

• 分子名：Il1a, interleukin 1 alpha
• 别称：
  • IL-1 alpha
  • IL-1F1
  • interleukin-1 alpha
• 基因序列：NCBI_Gene: 24493
• 蛋白序列：
  • UniprotKB: A0A0G2K003
  • UniprotKB: F1LQB1
  • UniprotKB: F1MAF9
  • UniprotKB: P16598

大鼠 Rat Il1a 靶点分子功能（预测）

Predicted to enable copper ion binding activity; cytokine activity; and interleukin-1 receptor binding activity. Involved in several processes, including keratinization; negative regulation of establishment of Sertoli cell barrier; and positive regulation of intracellular signal transduction. Located in several cellular components, including cell surface; cytosol; and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha).