Rat BDNF Standard (大鼠脑源性神经营养因子 (BDNF) 标准品)

BDNF 分子靶点信息概述

• 分子名：BDNF, brain derived neurotrophic factor
• 基因家族：Neurotrophins
• 全称：neurotrophin

BDNF 分子靶点综述

脑源性神经营养因子(BDNF)是生长因子神经营养素家族中的一员，与神经生长因子相关。神经营养因子存在于脑及外周。BDNF在内质网中加工合成，由致密核心囊泡分泌。它在大脑中的海马、皮层和基底前脑区域活跃，同样也在视网膜、运动神经元、肾脏、唾液和前列腺中表达。BDNF作用于中枢神经系统和外周神经系统的某些神经元，帮助现存神经元的存活、促进新生神经元和突触的生长和分化。BDNF的改变可能在精神分裂症的发病中起作用，与抑郁、湿疹、癫痫、阿尔茨海默病、肥胖、衰老、先天性中枢性低通气综合征和化疗后认知功能障碍有关。

大鼠 Rat Bdnf 分子靶点信息

• 分子名：Bdnf, brain-derived neurotrophic factor
• 别称：
  • Brain derived neurothrophic factor
  • brain derived neurotrophic factor
  • MGC105254
• 基因序列：NCBI_Gene: 24225
• 蛋白序列：
  • UniprotKB: A0A0G2K624
  • UniprotKB: A0A0H2UI28
  • UniprotKB: C8CEB1
  • UniprotKB: P23363
  • UniprotKB: Q99NV7

大鼠 Rat Bdnf 靶点分子功能（预测）

Enables neurotrophin TRKB receptor binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to norepinephrine stimulus; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of glucocorticoid receptor signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and synaptic vesicle. Used to study Alzheimer's disease; cystitis; eye disease (multiple); neuropathy (multiple); and status epilepticus. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; hypertensive encephalopathy; middle cerebral artery infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).