Human IL-9 Standard (人白细胞介素9标准品)

IL9 分子靶点信息概述

• 分子名：IL9, interleukin 9
• 基因家族：Interleukins
• 别名：IL-9; HP40; P40
• 全称：p40 T-cell and mast cell growth factor; T-cell growth factor p40; p40 cytokine; homolog of mouse T cell and mast cell growth factor 40

IL9 分子靶点综述

白细胞介素9(IL-9)是一个分子量为14kDa的糖基化蛋白，包含10个参与二硫键连接的半胱氨酸残基。它是由T细胞特别是CD4+辅助性细胞产生的细胞因子，可调节多种造血细胞。该细胞因子刺激细胞增殖、阻止细胞凋亡。它是通过与IL-9受体结合起作用的，可激活不同的信号转导及激活(STAT)蛋白，从而参与多种生物过程。编码该细胞因子的基因已被确定为哮喘的候选基因。小鼠模型的哮喘遗传研究表明，这种细胞因子是支气管高反应发病机制的一个决定性因素。IL-9介导的自分泌环的存在暗示着一些恶性肿瘤如霍奇金病的存在。IL-9由李-斯二氏细胞、霍奇金淋巴瘤细胞和一些大型再生障碍性淋巴瘤细胞表达，而非霍奇金淋巴瘤和外周T细胞淋巴瘤不表达。

人 Human IL9 分子靶点信息

• 分子名：IL9, interleukin 9
• 别称：
  • cytokine P40
  • homolog of mouse T cell and mast cell growth factor 40
  • HP40
  • IL-9
  • interleukin-9
  • P40
  • p40 cytokine
  • p40 T-cell and mast cell growth factor
  • T-cell growth factor p40
• 基因序列：NCBI_Gene: 3578
• 蛋白序列：UniProtKB: P15248

人 Human IL9靶点分子功能（预测）

Predicted to enable cytokine activity and interleukin-9 receptor binding activity. Predicted to be involved in positive regulation of interleukin-5 production. Predicted to act upstream of or within several processes, including B cell activation; regulation of cellular protein metabolic process; and regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in asthma and respiratory syncytial virus infectious disease. Biomarker of COVID-19; asthma; cystic fibrosis; lung disease (multiple); and rhinitis.