Mouse IL-33 High Sensitivity Standard (小鼠白细胞介素33高敏 标准品)

IL33 分子靶点信息概述

• 分子名：IL33, interleukin 33
• 基因家族：Interleukins
• 别名：DVS27; DKFZp586H0523; NF-HEV; IL1F11
• 曾用名：C9orf26
• 全称：DVS27-related protein; nuclear factor for high endothelial venules; interleukin-1 family, member 11; chromosome 9 open reading frame 26 (NF-HEV)

IL33 分子靶点综述

白细胞介素33(IL-33)也称为NF-HEV和DVS27，是IL-1家族成员，分子量为30kDa，由多种类型的细胞分泌，包括成纤维细胞、肥大细胞、树突细胞、巨噬细胞、成骨细胞、内皮细胞和上皮细胞。IL-33可诱导辅助性T细胞、肥大细胞、嗜酸性粒细胞和嗜碱性粒细胞分泌II型细胞因子。IL-33通过与受体ST2和IL-1受体辅助蛋白(IL1RAP)结合，活化可促使极化的Th2细胞分泌II型细胞因子(如IL-5和IL-13)的NF-κB和MAP激酶信号通路中的胞外分子来介导其生物学功能。注射IL-33后，其可在体内诱导II型细胞因子，这被认为可诱导粘膜器官发生严重的病理变化。

小鼠 Mouse Il33 分子靶点信息

• 分子名：Il33, interleukin 33
• 别称：
  • 9230117N10Rik
  • Il-33
  • Il1f11
  • NF-HEV
  • RIKEN cDNA 9230117N10 gene
• 基因序列：NCBI_Gene: 77125
• 蛋白序列：
  • UniprotKB: Q8BVZ5
  • UniprotKB: D3Z6T7
  • UniprotKB: E9M2E8
  • UniprotKB: H3BKB5
  • UniprotKB: H3BLN5

小鼠 Mouse Il33 靶点分子功能（预测）

Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; microglial cell activation involved in immune response; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33).