Rat IL-18 Standard (大鼠白细胞介素18 标准品)

IL18 分子靶点信息概述

• 分子名：IL18, interleukin 18
• 基因家族：Interleukins
• 别名：IGIF; IL1F4; IL-1g; IL-18
• 全称：interferon-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor)

IL18 分子靶点综述

白细胞介素18(IL-18)，又名干扰素γ诱导因子，是一种促炎性细胞因子，在人类中由IL18基因编码。IL-18属于IL-1超家族，由巨噬细胞和其它细胞分泌产生。IL-18刺激后，自然杀伤细胞(NK)和某些T细胞就会释放另一种重要的细胞因子—干扰素γ或Ⅱ型干扰素，进而激活巨噬细胞或其它细胞。IL-18可诱导产生严重的炎症反应，同样可增加人类神经元中β-淀粉样蛋白(与阿尔茨海默氏病相关)的产生。

大鼠 Mouse Il18 分子靶点信息

• 分子名：Il18, interleukin 18
• 别称：
  • IFN-gamma-inducing factor
  • IL-1 gamma
  • IL-18
  • interferon gamma-inducing factor
  • interferon-gamma-inducing factor
  • interleukin-1 gamma
  • interleukin-18
• 基因序列：NCBI_Gene: 29197
• 蛋白序列：
  • UniprotKB: P97636
  • UniprotKB: Z4YNI9

大鼠 Rat Il18 靶点分子功能（预测）

Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane; cytoplasm; and extracellular space. Used to study brain edema; fatty liver disease; heart disease; status epilepticus; and vasculitis. Biomarker of several diseases, including cardiac arrest; ischemia (multiple); lung disease (multiple); perinatal necrotizing enterocolitis; and urinary tract infection. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).