Mouse IL-18 ELISA Kit检测试剂盒(酶联免疫吸附法)
¥1,600.00 – ¥2,650.00
在售SKU:70-EK218-48, 70-EK218-96, EK218
- 分子靶点:IL18
- 种属:小鼠
- 样本类型:血清、血浆、细胞培养上清及其他生物学样本
- 检测样本体积:血清血浆:20μL;细胞培养上清:100μL
- 灵敏度:0.93pg/mL
- 检测范围:62.5-4000pg/mL
- 回收率:80%-119%
ELISA试剂盒详细信息
商品名 | 小鼠白介素18酶联免疫检测试剂盒 |
---|---|
种属 | 小鼠 |
靶点 | IL18 |
检测方法 | 双抗体夹心法 |
检测样本类型 | 血清、血浆、细胞培养上清及其他生物学样本 |
检测样本体积 | 血清血浆:20μL;细胞培养上清:100μL |
灵敏度 | 0.93pg/mL |
线性范围 | 62.5-4000pg/mL |
精密度 | 板内变异系数:2.7%-4.0%;板间变异系数:2.4%-3.7% |
回收率 | 80%-119% |
平均回收率 | 98% |
板式 | 96孔板,可拆 |
保存条件 | 2-8℃保存。已拆开:标准品-20℃保存,其它4℃。 |
运输条件 | 2-8℃冰袋运输 |
检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗小鼠IL-18抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、检测样本和辣根过氧化物酶标记的检测抗体,经过孵育,样本中存在的IL-18与固相抗体结合和检测抗体结合。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中IL-18的浓度成正比。加入终止液终止反应,在450nm波长(参考波长570 - 630nm)测定吸光度值。 |
分子信息
IL18 分子靶点信息概述
- 分子名:IL18, interleukin 18
- 基因家族:Interleukins
- 别名:IGIF; IL1F4; IL-1g; IL-18
- 全称:interferon-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor)
IL18 分子靶点综述
白细胞介素18(IL-18),又名干扰素γ诱导因子,是一种促炎性细胞因子,在人类中由IL18基因编码。IL-18属于IL-1超家族,由巨噬细胞和其它细胞分泌产生。IL-18刺激后,自然杀伤细胞(NK)和某些T细胞就会释放另一种重要的细胞因子—干扰素γ或Ⅱ型干扰素,进而激活巨噬细胞或其它细胞。IL-18可诱导产生严重的炎症反应,同样可增加人类神经元中β-淀粉样蛋白(与阿尔茨海默氏病相关)的产生。
小鼠 Mouse Il18 分子靶点信息
- 分子名:Il18, interleukin 18
- 别称:
- Igif
- Il-18
- interferon gamma inducing factor
- 基因序列:NCBI_Gene: 16173
- 蛋白序列:
小鼠 Mouse Il18 靶点分子功能(预测)
Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).
引用文献统计
该产品被引用的文献总数为:162
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影响因子:6.17刊物:FREE RADICAL BIOLOGY AND MEDICINE发表日期:2020/7/17 - 6-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response in mice through the NF-κB pathway
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影响因子:13.391刊物:Autophagy发表日期:2022/8/8 - Mycobacterium tuberculosis PE_PGRS19 Induces Pyroptosis through a Non-Classical Caspase-11/GSDMD Pathway in Macrophages
影响因子:4.926刊物:Microorganisms发表日期:2022/12/14 - Resveratrol affects the expression of uric acid transporter by improving inflammation
影响因子:2.952刊物:Molecular Medicine Reports发表日期:2021/6/7 - AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress
影响因子:6.876刊物:CLINICAL SCIENCE发表日期:2022/1/7 - Knockdown of TLR4 attenuates high glucose-induced podocyte injury via the NALP3/ASC/Caspase-1 signaling pathway
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影响因子:7.36刊物:CANCER LETTERS发表日期:2020/8/27 - Natural molecule Munronoid I attenuates LPS-induced acute lung injury by promoting the K48-linked ubiquitination and degradation of TAK1
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