Human TRANCE/TNFSF11/RANKL Standard (人 TRANCE/TNFSF11/RANKL 标准品)

TNFSF11 分子靶点信息概述

• 分子名：TNFSF11, TNF superfamily member 11
• 基因家族：CD molecules; Tumor necrosis factor superfamily
• 别名：TRANCE; RANKL; OPGL; ODF; CD254
• 全称：tumor necrosis factor (ligand) superfamily, member 11

TNFSF11 分子靶点综述

肿瘤坏死因子相关激活诱导因子(TRANCE)，又名肿瘤坏死因子配体超家族成员11(TNFSF11)、核因子κB受体活化因子配基(RANKL)，是TNF超家族成员。成骨细胞、CD4+和CD8+T细胞、巨核细胞、支气管和肠道上皮细胞等都可表达TRANCE。TRANCE在免疫应答和骨形态发生中起核心作用。在骨形成和重塑过程中，成骨细胞表达的TRANCE与M-CSF一起诱导破骨细胞形成和活化，导致骨吸收，进而导致随后的骨沉积和重塑。TRANCE同样在病理性骨质疏松中起作用。活化的淋巴细胞和成骨细胞不恰当表达TRANCE就会导致关节和骨头的过度吸收与沉积。过量的TRANCE与许多退行性骨疾病，如类风湿性关节炎、银屑病性关节炎有关。

人 Human TNFSF11 分子靶点信息

• 分子名：TNFSF11, TNF superfamily member 11
• 别称：
  • CD254
  • hRANKL2
  • ODF
  • OPGL
  • OPTB2
  • osteoclast differentiation factor
  • osteoprotegerin ligand
  • RANKL
  • receptor activator of nuclear factor kappa B ligand
  • receptor activator of nuclear factor kappa-B ligand
  • sOdf
  • TNF-related activation-induced cytokine
  • TNLG6B
  • TRANCE
  • tumor necrosis factor (ligand) superfamily member 11
  • tumor necrosis factor (ligand) superfamily, member 11
  • tumor necrosis factor ligand 6B
  • tumor necrosis factor ligand superfamily member 11
  • tumor necrosis factor superfamily member 11
• 基因序列：NCBI_Gene: 8600
• 蛋白序列：UniProtKB: O14788

人 Human TNFSF11靶点分子功能（预测）

Enables cytokine activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of cell-cell adhesion; and regulation of transcription, DNA-templated. Predicted to be located in extracellular region and plasma membrane. Implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Biomarker of myocardial infarction.