Human Tie1 Standard (人酪氨酸蛋白激酶受体Tie1 标准品)

TIE1 分子靶点信息概述

• 分子名：TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1
• 基因家族：Receptor tyrosine kinases; Fibronectin type III domain containing; Immunoglobulin like domain containing
• 别名：JTK14
• 曾用名：TIE
• 全称：tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1

TIE1 分子靶点综述

酪氨酸蛋白激酶受体Tie1是一个单次跨膜的I型膜蛋白，属于蛋白激酶超家族、酪氨酸蛋白激酶家族和Tie亚家族。Tie1有三个EGF样结构域、三个纤连蛋白III型结构域、两个免疫球蛋白样C2型结构域和一个蛋白激酶结构域。Tie1是一个专门在内皮细胞中表达的细胞表面蛋白，然而，研究表明它同样也可在不成熟的造血细胞和血小板中表达。在血管发育的毛细管涌现阶段，Tie1对于微血管内皮细胞的存活和生长是必需的。Tie1通过p38依赖性机制上调细胞粘附分子VCAM-1、E-selectin和ICAM-1。Tie1的表达可增强单核细胞来源的免疫细胞粘附于内皮细胞。Tie1具有促炎症性效果，在内皮的炎症性疾病如动脉粥样硬化中起重要作用。

人 Human TIE1 分子靶点信息

• 分子名：TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1
• 别称：
  • JTK14
  • LMPHM11
  • receptor tyrosine kinase
  • soluble TIE1 variant 1
  • soluble TIE1 variant 2
  • soluble TIE1 variant 3
  • soluble TIE1 variant 4
  • soluble TIE1 variant 5
  • TIE
  • tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1
  • tyrosine-protein kinase receptor Tie-1
• 基因序列：NCBI_Gene: 7075
• 蛋白序列：UniProtKB: P35590

人 Human TIE1靶点分子功能（预测）

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including circulatory system development; positive regulation of angiogenesis; and positive regulation of kinase activity. Predicted to act upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Implicated in hereditary lymphedema.