Human/Mouse TGF-β1 Standard (人/小鼠转化生长因子β1 标准品)

TGFB1 分子靶点信息概述

• 分子名：TGFB1, transforming growth factor beta 1
• 基因家族：Transforming growth factor beta family
• 别名：CED; TGFbeta
• 曾用名：TGFB; DPD1
• 全称：Camurati-Engelmann disease; prepro-transforming growth factor beta-1; Diaphyseal dysplasia 1, progressive; transforming growth factor, beta 1

TGFB1 分子靶点综述

转化生长因子β1 (TGF-β1)是转化生长因子β超家族的多肽成员，具有多种细胞学功能，包括调控细胞生长、增殖、分化和凋亡。TGF-β与TGFA协同诱导转化。它也能作为负向自分泌生长因子。TGF-β活化和信号传导的失调可能会引起凋亡。很多细胞可合成TGF-β，且几乎都有特异性的受体。TGF-β1、TGF-β2和TGF-β3都通过相同的受体信号通路发挥功能。TGF-β1对调控免疫系统具有重要作用，对不同类型的细胞或不同发育阶段的细胞具有不同的活性。大部分免疫细胞 (或白细胞) 分泌TGF-β1。TGF-β1与癌症、自身免疫疾病、肝脏疾病、肾脏疾病、糖尿病、心血管疾病、哮喘、慢性阻塞性肺疾病 (COPD)和囊肿性纤维化 (CF) 等相关。

人 Human TGFB1 分子靶点信息

• 分子名：TGFB1, transforming growth factor beta 1
• 别称：
  • CED
  • DPD1
  • IBDIMDE
  • LAP
  • latency-associated peptide
  • prepro-transforming growth factor beta-1
  • TGF-beta 1 protein
  • TGF-beta-1
  • TGF-beta1
  • TGFB
  • TGFbeta
  • transforming growth factor beta-1
  • transforming growth factor beta-1 proprotein
  • transforming growth factor beta1
• 基因序列：NCBI_Gene: 7040
• 蛋白序列：UniProtKB: P01137

人 Human TGFB1靶点分子功能（预测）

Enables several functions, including antigen binding activity; identical protein binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within epithelial to mesenchymal transition; negative regulation of gene expression; and positive regulation of isotype switching to IgA isotypes. Located in several cellular components, including cell surface; extracellular space; and nucleus. Colocalizes with microvillus. Implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and lung disease (multiple).