Human MMP-2 Standard (人基质金属蛋白酶2 标准品)

MMP2 分子靶点信息概述

• 分子名：MMP2, matrix metallopeptidase 2
• 基因家族：M10 matrix metallopeptidases
• 别名：TBE-1
• 曾用名：CLG4; CLG4A
• 全称：matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

MMP2 分子靶点综述

基质金属蛋白酶2(MMP-2)，又名72kDa的IV型胶原酶和明胶酶A，在人类中由MMP2基因编码。激活MMP-2需要蛋白水解加工。MMP-2在子宫内膜破裂、调节血管形成和炎症应答中起作用。MMP-2参与许多事件，如癌症进程、癌细胞浸润、细胞信号转导、新血管形成和淋巴管生成。MMP2基因突变与Torg-Winchester综合征、多发性骨溶解、关节炎综合征有关，可能与瘢痕疙瘩有关。非囊性纤维化支气管扩张中，相比于呼吸道感染铜绿假单胞菌的患者，感染流感嗜血杆菌患者的MMP-2浓度是升高的。

人 Human MMP2 分子靶点信息

• 分子名：MMP2, matrix metallopeptidase 2
• 别称：
  • 72 kDa gelatinase
  • 72 kDa type IV collagenase
  • CLG4
  • CLG4A
  • collagenase type IV-A
  • gelatinase A
  • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • matrix metalloproteinase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase)
  • matrix metalloproteinase-2
  • matrix metalloproteinase-II
  • MMP-2
  • MMP-II
  • MONA
  • neutrophil gelatinase
  • TBE-1
• 基因序列：NCBI_Gene: 4313
• 蛋白序列：UniProtKB: P08253

人 Human MMP2靶点分子功能（预测）

Enables metallopeptidase activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to UV-A; endodermal cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Biomarker of several diseases, including artery disease (multiple); carcinoma (multiple); cardiomyopathy (multiple); cholesteatoma (multiple); and neurodegenerative disease (multiple).