Human C-Reactive Protein/CRP Standard (人C-反应蛋白 标准品)

CRP 分子靶点信息概述

• 分子名：CRP, C-reactive protein
• 基因家族：Short pentraxins
• 别名：PTX1
• 全称：pentraxin 1; C-reactive protein, pentraxin-related

CRP 分子靶点综述

C-反应蛋白(CRP)是在血浆中发现的一种环状、五聚体蛋白。肝脏对巨噬细胞和脂肪细胞释放的因子产生应答后可合成CRP。CRP是一种肝源性的急性蛋白，在巨噬细胞和T细胞分泌白介素6后增加，其生理作用是与死细胞或濒死细胞(和某些类型的细菌)表面的溶血磷脂胆碱结合，以通过C1Q复合物来激活补体系统。它与C-肽(胰岛素)或蛋白C(血凝)不相关。CRP通常作为炎症标志物，当机体受到炎症感染时，CRP水平会上升。最近的研究表明，患者具有较高基础水平的CRP，通常伴随着一个较高糖尿病、高血压和心血管疾病的发生率。

人 Human CRP 分子靶点信息

• 分子名：CRP, C-reactive protein
• 别称：
  • C-reactive protein, pentraxin-related
  • c-reactive protein, petaxin related
  • MGC149895
  • MGC88244
  • pentraxin 1
  • PTX1
• 基因序列：NCBI_Gene: 1401
• 蛋白序列：UniProtKB: P02741

人 Human CRP靶点分子功能（预测）

Enables several functions, including complement component C1q complex binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including negative regulation of macrophage derived foam cell differentiation; positive regulation of superoxide anion generation; and regulation of gene expression. Acts upstream of or within vasoconstriction. Located in extracellular space. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Biomarker of several diseases, including artery disease (multiple); auditory system disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple).