Human CCL11/Eotaxin Standard (人趋化因子配体11 标准品)

CCL11 分子靶点信息概述

• 分子名：CCL11, C-C motif chemokine ligand 11
• 基因家族：Chemokine ligands
• 别名：eotaxin; MGC22554
• 曾用名：SCYA11
• 全称：eotaxin-1; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); chemokine (C-C motif) ligand 11

CCL11 分子靶点综述

趋化因子配体11(CCL11)也称为嗜酸性粒细胞趋化因子(Eotaxin)，是CC趋化因子家族中的小分子量细胞因子。Eotaxin通过诱导嗜酸性粒细胞的趋化性进行选择性招募，因此参与变态反应。Eotaxin在人和小鼠血浆中的表达升高与其衰老有关。相比于曾经吸食大麻者和从未吸食大麻者，目前仍在吸食大麻者的血浆中含有更高浓度的Eotaxin。精神分裂者体内的Eotaxin浓度也更高，而大麻正是已知的精神分裂症诱导剂。

人 Human CCL11 分子靶点信息

• 分子名：CCL11, C-C motif chemokine ligand 11
• 别称：
  • C-C motif chemokine 11
  • chemokine (C-C motif) ligand 11
  • eosinophil chemotactic protein
  • eotaxin
  • eotaxin-1
  • MGC22554
  • SCYA11
  • small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
  • small-inducible cytokine A11
• 基因序列：NCBI_Gene: 6356
• 蛋白序列：UniProtKB: P51671

人 Human CCL11靶点分子功能（预测）

Enables CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including eosinophil chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Located in extracellular region. Implicated in asthma; human immunodeficiency virus infectious disease; and hyperglycemia. Biomarker of several diseases, including cystic fibrosis; hyperglycemia; lung disease (multiple); nephrotic syndrome type 1; and ureteral obstruction.