Human Serpin E1/PAI-1 Standard (人Serpin E1/纤溶酶原激活物抑制因子-1 (PAI-1) 标准品)

SERPINE1 分子靶点信息概述

• 分子名：SERPINE1, serpin family E member 1
• 基因家族：Serpin peptidase inhibitors
• 别名：PAI
• 曾用名：PLANH1; PAI1
• 全称：plasminogen activator inhibitor, type I; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

SERPINE1 分子靶点综述

Serpin E1，又名纤溶酶原激活物抑制因子-1 (PAI-1)，是丝氨酸蛋白酶抑制剂超家族中的一员，主要由内皮(血管内皮衬里细胞)产生，但也由其他类型的组织如脂肪组织分泌产生。Serpin E1是尿激酶和组织型纤溶酶原激活剂(uPA和tPA)的主要抑制剂。PA-血纤维蛋白溶酶系统参与多种生理和病理过程如纤维蛋白溶解、纤维化、血管生成、伤口愈合、肿瘤细胞的侵袭和转移。例如，高水平的uPA和Serpin E1与乳腺癌患者的预后不良相关，研究证实uPA和Serpin E1的临床价值处于1级水平，是最可靠的生物标志物。除了乳腺癌，Serpin E1也参与许多其它疾病如代谢综合征、哮喘、重度抑郁症(MDD)以及衰老相关疾病。血浆中Serpin E1的缺失将导致异常出血，高水平的Serpin E1与遗传性易栓症相关。

人 Human SERPINE1 分子靶点信息

• 分子名：SERPINE1, serpin family E member 1
• 别称：
  • endothelial plasminogen activator inhibitor
  • PAI
  • PAI-1
  • PAI1
  • PLANH1
  • plasminogen activator inhibitor 1
  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • serpin E1
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
• 基因序列：NCBI_Gene: 5054
• 蛋白序列：UniProtKB: P05121

人 Human SERPINE1靶点分子功能（预测）

Enables protease binding activity; serine-type endopeptidase inhibitor activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of proteolysis; regulation of angiogenesis; and response to bacterium. Located in collagen-containing extracellular matrix and extracellular exosome. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); lung disease (multiple); and sleep apnea (multiple).