Genipin-Crosslinked Human Serum Albumin Coating Using a Tannic Acid Layer for Enhanced Oral Administration of Curcumin in the Treatment of Ulcerative Colitis

  • 作者:Luo, R., Lin, M., Zhang, C., Shi, J., Zhang, S., Chen, Q., Hu, Y., Zhang, M., Zhang, J. & Gao, F.
  • 期刊:Food chemistry 330, 127241 (2020)
  • 阅读原文

Curcumin (CUR) is a promising edible phytochemical compound with ideal ulcerative colitis (UC) treatment activity; however, it is characteristically instable in the digestive tract and has a short retention time in colon. Therefore, we designed and fabricated an oral food-grade nanocarrier composed of tannic acid (TA)-coated, Genipin (Gnp)-crosslinked human serum albumin (HSA) to encapsulate CUR (TA/CUR-NPs). The resulting CUR nanoparticles (NPs) were about 220?nm and -28.8?mV. With the assistance of TA layer and Gnp-crosslinking, the entire nano-scaled system effectively delayed CUR release in simulated gastric fluid, prolonged its colon adhesion and increased its uptake in Caco-2 cells. As expected, TA/CUR-NPs oral administration significantly alleviated colitis symptoms in DSS-treated mice when compared with controls by inhibiting the TLR4-linked NF-κB signaling pathway. Collectively, this study indicates that we have developed a convenient, eco-friendly, nano-scaled vehicle for oral delivery of CUR with anti-UC benefit.