Rat VEGF High Sensitivity Standard (大鼠血管内皮生长因子高敏 标准品)

VEGFA 分子靶点信息概述

• 分子名：VEGFA, vascular endothelial growth factor A
• 基因家族：VEGF family
• 别名：VEGF-A; VPF
• 曾用名：VEGF
• 全称：vascular endothelial growth factor

VEGFA 分子靶点综述

血管内皮生长因子(VEGF)是生长因子的亚家族，具体来说，属于胱氨酸结生长因子中的血小板衍生生长因子(PDGF)家族。它们是重要的信号转导蛋白，参与血管发生(胚胎循环系统从头形成)和血管生成(从已存在的脉管系统生长形成血管)。VEGF可刺激血管发生和血管生成。当血液循环不足时，可参与回复组织供氧系统。VEGF最主要的作用是血管生成。在胚胎形成期，VEGF调控内皮细胞的增殖、迁移和存活，从而调控血管密度和大小，但无法决定血管的类型。在支气管哮喘和糖尿病患者的血清中含有高浓度VEGF。当VEGF过表达时会引起疾病。供血不足时，实体肿瘤的大小受限；而表达VEGF的肿瘤则会不断生长并发生转移。VEGF过表达会导致眼睛视网膜和身体其他部分的血管性疾病。贝伐珠单抗和雷珠单抗可抑制VEGF，并控制或减缓疾病进程。

大鼠 Rat Vegfa 分子靶点信息

• 分子名：Vegfa, vascular endothelial growth factor A
• 别称：
  • vascular endothelial growth factor
  • vascular permeability factor
  • Vegf
  • VEGF-A
  • VEGF111
  • VEGF164
  • VPF
• 基因序列：NCBI_Gene: 83785
• 蛋白序列：
  • UniprotKB: A0A0G2K6Z7
  • UniprotKB: A0A0H2UHY5
  • UniprotKB: B5DEK7
  • UniprotKB: F1M6X1
  • UniprotKB: F8WG85
  • UniprotKB: G8JLS5
  • UniprotKB: P16612
  • UniprotKB: Q541S7
  • UniprotKB: Q91ZE2

大鼠 Rat Vegfa 靶点分子功能（预测）

Enables several functions, including identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of cell death; response to steroid hormone; and response to vitamin. Located in basement membrane; extracellular space; and vesicle. Used to study several diseases, including brain edema; limb ischemia; middle cerebral artery infarction; ovarian hyperstimulation syndrome; and proliferative diabetic retinopathy. Biomarker of several diseases, including adhesions of uterus; attention deficit hyperactivity disorder; brain edema; liver disease (multiple); and retinal vascular disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).