文章目录[隐藏]
- VEGFA 分子靶点信息概述
- VEGFA 分子靶点综述
- VEGFA, vascular endothelial growth factor A 分子靶点种属信息
- VEGFA 分子产品列表
- EasyGo!™ Human VEGF One-Step ELISA Kit EasyGo!™ 人血管内皮生长因子 (VEGF) 一步法酶联免疫吸附测定试剂盒
- Rat VEGF High Sensitivity Standard (大鼠血管内皮生长因子高敏 标准品)
- Rat VEGF Standard (大鼠血管内皮生长因子 标准品)
- Rat VEGF ELISA Kit检测试剂盒(酶联免疫吸附法)
- Rat VEGF High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
- Mouse VEGF ELISA Kit检测试剂盒(酶联免疫吸附法)
- Mouse VEGF Standard (小鼠血管内皮生长因子 标准品)
- Human VEGF Standard (人血管内皮生长因子 (VEGF) 标准品)
- Human VEGF ELISA Kit检测试剂盒(酶联免疫吸附法)
- VEGFA 分子靶点最新资讯
VEGFA 分子靶点信息概述
- 分子名:VEGFA, vascular endothelial growth factor A
- 基因家族:VEGF family
- 别名:VEGF-A; VPF
- 曾用名:VEGF
- 全称:vascular endothelial growth factor
VEGFA 分子靶点综述
血管内皮生长因子(VEGF)是生长因子的亚家族,具体来说,属于胱氨酸结生长因子中的血小板衍生生长因子(PDGF)家族。它们是重要的信号转导蛋白,参与血管发生(胚胎循环系统从头形成)和血管生成(从已存在的脉管系统生长形成血管)。VEGF可刺激血管发生和血管生成。当血液循环不足时,可参与回复组织供氧系统。VEGF最主要的作用是血管生成。在胚胎形成期,VEGF调控内皮细胞的增殖、迁移和存活,从而调控血管密度和大小,但无法决定血管的类型。在支气管哮喘和糖尿病患者的血清中含有高浓度VEGF。当VEGF过表达时会引起疾病。供血不足时,实体肿瘤的大小受限;而表达VEGF的肿瘤则会不断生长并发生转移。VEGF过表达会导致眼睛视网膜和身体其他部分的血管性疾病。贝伐珠单抗和雷珠单抗可抑制VEGF,并控制或减缓疾病进程。
VEGFA, vascular endothelial growth factor A 分子靶点种属信息
人 Human VEGFA 分子靶点信息
- 分子名:VEGFA, vascular endothelial growth factor A
- 别称:
- MGC70609
- MVCD1
- vascular endothelial growth factor
- vascular endothelial growth factor A121
- vascular endothelial growth factor A165
- vascular permeability factor
- VEGF
- VEGF-A
- VPF
- 基因序列:NCBI_Gene: 7422
- 蛋白序列:UniProtKB: P15692
人 Human VEGFA靶点分子功能(预测)
Enables several functions, including fibronectin binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of endothelial cell proliferation; and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including adherens junction; cell surface; and secretory granule. Implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); inflammatory bowel disease (multiple); and respiratory system cancer (multiple).
小鼠 Mouse Vegfa 分子靶点信息
- 分子名:Vegfa, vascular endothelial growth factor A
- 别称:
- vascular endothelial growth factor
- Vegf
- VEGF-A
- VEGF120
- VEGF164
- VEGF188
- VPF
- 基因序列:NCBI_Gene: 22339
- 蛋白序列:
小鼠 Mouse Vegfa 靶点分子功能(预测)
Enables extracellular matrix binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including generation of neurons; regulation of signal transduction; and vasculature development. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including alimentary system; brain; egg cylinder; genitourinary system; and heart. Used to study DiGeorge syndrome; amyotrophic lateral sclerosis type 1; newborn respiratory distress syndrome; and psoriasis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
大鼠 Rat Vegfa 分子靶点信息
- 分子名:Vegfa, vascular endothelial growth factor A
- 别称:
- vascular endothelial growth factor
- vascular permeability factor
- Vegf
- VEGF-A
- VEGF111
- VEGF164
- VPF
- 基因序列:NCBI_Gene: 83785
- 蛋白序列:
大鼠 Rat Vegfa 靶点分子功能(预测)
Enables several functions, including identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of cell death; response to steroid hormone; and response to vitamin. Located in basement membrane; extracellular space; and vesicle. Used to study several diseases, including brain edema; limb ischemia; middle cerebral artery infarction; ovarian hyperstimulation syndrome; and proliferative diabetic retinopathy. Biomarker of several diseases, including adhesions of uterus; attention deficit hyperactivity disorder; brain edema; liver disease (multiple); and retinal vascular disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
VEGFA 分子产品列表
-
- EK183EGA
- 一步法ELISA试剂盒
EasyGo!™ Human VEGF One-Step ELISA Kit EasyGo!™ 人血管内皮生长因子 (VEGF) 一步法酶联免疫吸附测定试剂盒
- ¥2,190.00 – ¥3,650.00
-
- EK383HSS
- ELISA标准品
Rat VEGF High Sensitivity Standard (大鼠血管内皮生长因子高敏 标准品)
- ¥280.00
-
- EK383S
- ELISA标准品
Rat VEGF Standard (大鼠血管内皮生长因子 标准品)
- ¥180.00
-
- EK383
- ELISA试剂盒
Rat VEGF ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
-
- EK383HS
- 高敏试剂盒
Rat VEGF High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥2,000.00 – ¥3,400.00
-
- EK283
- ELISA试剂盒
Mouse VEGF ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
-
- EK283S
- ELISA标准品
Mouse VEGF Standard (小鼠血管内皮生长因子 标准品)
- ¥180.00
-
- EK183S
- ELISA标准品
Human VEGF Standard (人血管内皮生长因子 (VEGF) 标准品)
- ¥280.00
-
- EK183
- ELISA试剂盒
Human VEGF ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥10,800.00