Rat IL-17A Standard (大鼠白细胞介素17A 标准品)

IL17A 分子靶点信息概述

• 分子名：IL17A, interleukin 17A
• 基因家族：Interleukins
• 别名：IL-17A; IL-17
• 曾用名：CTLA8; IL17
• 全称：cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

IL17A 分子靶点综述

IL-17主要由Th17型细胞产生，是目前已发现的30余种白细胞介素中的一员，按序号排在第17位。该家族包括6个成员配体(IL-17A ~ IL-17F)和5个受体(IL-17RA ~ IL-17RD和SEF)。IL-17是一种主要由活化的T细胞产生的致炎细胞因子，可以促进T细胞的激活和刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子，从而导致炎症的产生。

大鼠 Rat Il17a 分子靶点信息

• 分子名：Il17a, interleukin 17A
• 别称：
  • CTLA-8
  • cytotoxic T-lymphocyte-associated antigen 8
  • hypothetical protein LOC301289
  • IL-17
  • IL-17A
  • Il17
  • interleukin 17
  • Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
  • interleukin-17A
  • LOC301289
  • similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
• 基因序列：NCBI_Gene: 301289
• 蛋白序列：
  • UniprotKB: G3V7M4
  • UniprotKB: Q61453

大鼠 Rat Il17a 靶点分子功能（预测）

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A).