Anti-Human IL-17A, PE (Clone:BL168)检测试剂

IL17A 分子靶点信息概述

• 分子名：IL17A, interleukin 17A
• 基因家族：Interleukins
• 别名：IL-17A; IL-17
• 曾用名：CTLA8; IL17
• 全称：cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

IL17A 分子靶点综述

IL-17主要由Th17型细胞产生，是目前已发现的30余种白细胞介素中的一员，按序号排在第17位。该家族包括6个成员配体(IL-17A ~ IL-17F)和5个受体(IL-17RA ~ IL-17RD和SEF)。IL-17是一种主要由活化的T细胞产生的致炎细胞因子，可以促进T细胞的激活和刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子，从而导致炎症的产生。

人 Human IL17A 分子靶点信息

• 分子名：IL17A, interleukin 17A
• 别称：
  • CTLA-8
  • CTLA8
  • cytotoxic T-lymphocyte-associated antigen 8
  • cytotoxic T-lymphocyte-associated protein 8
  • cytotoxic T-lymphocyte-associated serine esterase 8
  • IL-17
  • IL-17A
  • IL17
  • ILA17
  • interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
  • interleukin-17
  • interleukin-17A
• 基因序列：NCBI_Gene: 3605
• 蛋白序列：UniProtKB: Q16552

人 Human IL17A靶点分子功能（预测）

Predicted to enable cytokine activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of osteoclast differentiation. Acts upstream of or within positive regulation of cytokine production and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Biomarker of several diseases, including acne; autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and rhinitis (multiple).