IL1A 靶点信息

IL1A 分子靶点信息概述

  • 分子名：IL1A, interleukin 1 alpha
  • 基因家族：Interleukins
  • 别名：IL1F1; IL-1A; IL1-ALPHA
  • 曾用名：IL1
  • 全称：preinterleukin 1 alpha; hematopoietin-1; pro-interleukin-1-alpha

IL1A 分子靶点综述

白细胞介素1(IL-1)是17kDa的胞外多肽，分为IL-1α和IL-1β两种蛋白。IL-1α是一种多效性细胞因子，在人类中由IL1A基因编码。IL-1α主要由活化的巨噬细胞、中性粒细胞、上皮细胞和内皮细胞产生。它具有代谢、生理、造血活性，在调节免疫应答中起到核心作用。IL-1α可与HAX1、NDN相互作用，但是与TNF之间的协同作用是临床上最相关的。IL-1α和TNF都是急性期细胞因子，具有促发热和发炎作用。人们目前正在评估IL-1α是否可作为临床试验中一个潜在治疗肿瘤的标志物。阻断IL-1α活性具有潜在治疗皮肤病的作用，例如痤疮。

IL1A, interleukin 1 alpha 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL1A 分子靶点信息

  • 分子名：IL1A, interleukin 1 alpha
  • 别称：
    • hematopoietin-1
    • IL-1 alpha
    • IL-1A
    • IL1
    • IL1-ALPHA
    • IL1F1
    • interleukin 1, alpha
    • interleukin-1 alpha
    • preinterleukin 1 alpha
    • pro-interleukin-1-alpha
  • 基因序列：NCBI_Gene: 3552
  • 蛋白序列：UniProtKB: P01583

人 Human IL1A靶点分子功能（预测）

Enables copper ion binding activity and cytokine activity. Involved in several processes, including positive regulation of interleukin-2 production; positive regulation of mitotic nuclear division; and response to copper ion. Located in cytosol and extracellular space. Implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Biomarker of several diseases, including autoimmune disease (multiple); cholesteatoma (multiple); common cold; cystic fibrosis; and osteoarthritis.

小鼠 Mouse Il1a 分子靶点信息

小鼠 Mouse Il1a 靶点分子功能（预测）

Enables cytokine activity and interleukin-1 receptor binding activity. Involved in positive regulation of angiogenesis and positive regulation of vascular endothelial growth factor production. Acts upstream of or within several processes, including cell surface receptor signaling pathway; connective tissue replacement involved in inflammatory response wound healing; and positive regulation of cytokine production. Located in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha).

大鼠 Rat Il1a 分子靶点信息

大鼠 Rat Il1a 靶点分子功能（预测）

Predicted to enable copper ion binding activity; cytokine activity; and interleukin-1 receptor binding activity. Involved in several processes, including keratinization; negative regulation of establishment of Sertoli cell barrier; and positive regulation of intracellular signal transduction. Located in several cellular components, including cell surface; cytosol; and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha).

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