Mouse Leptin Standard (小鼠瘦素 标准品)

LEP 分子靶点信息概述

• 分子名：LEP, leptin
• 基因家族：Neuropeptides
• 曾用名：OBS; OB
• 全称：leptin (murine obesity homolog); leptin (obesity homolog, mouse)

LEP 分子靶点综述

瘦素是由脂肪细胞分泌的蛋白质类激素，可通过抑制饥饿来调控能量平衡。除了白色脂肪组织可以分泌瘦素外，褐色脂肪、胎盘、卵巢、骨骼肌、胃、乳腺上皮细胞、骨髓和P/D1细胞也能产生瘦素。瘦素和饥饿激素都作用于下丘脑弓状核的受体，以此来调节食欲，获得能量平衡。瘦素的基本功能是调节脂肪储存，但它在其它生理代谢过程中同样发挥作用，然而许多其它功能还未明确。研究表明瘦素与肥胖和减肥有关联。

小鼠 Mouse Lep 分子靶点信息

• 分子名：Lep, leptin
• 别称：
  • ob
  • obese
• 基因序列：NCBI_Gene: 16846
• 蛋白序列：
  • UniprotKB: P41160
  • UniprotKB: A0A1C9CJK6
  • UniprotKB: E9M0G2
  • UniprotKB: E9Q7Z0
  • UniprotKB: Q544U0

小鼠 Mouse Lep 靶点分子功能（预测）

Enables DNA binding activity and growth factor activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including insulin secretion; monocarboxylic acid metabolic process; and regulation of insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple); fatty liver disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin).