LEP 靶点信息

LEP 分子靶点信息概述

  • 分子名：LEP, leptin
  • 基因家族：Neuropeptides
  • 曾用名：OBS; OB
  • 全称：leptin (murine obesity homolog); leptin (obesity homolog, mouse)

LEP 分子靶点综述

瘦素是由脂肪细胞分泌的蛋白质类激素，可通过抑制饥饿来调控能量平衡。除了白色脂肪组织可以分泌瘦素外，褐色脂肪、胎盘、卵巢、骨骼肌、胃、乳腺上皮细胞、骨髓和P/D1细胞也能产生瘦素。瘦素和饥饿激素都作用于下丘脑弓状核的受体，以此来调节食欲，获得能量平衡。瘦素的基本功能是调节脂肪储存，但它在其它生理代谢过程中同样发挥作用，然而许多其它功能还未明确。研究表明瘦素与肥胖和减肥有关联。

LEP, leptin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human LEP 分子靶点信息

  • 分子名：LEP, leptin
  • 别称：
    • FLJ94114
    • LEPD
    • leptin (murine obesity homolog)
    • leptin (obesity homolog, mouse)
    • OB
    • obese protein
    • obese, mouse, homolog of
    • obesity factor
    • OBS
  • 基因序列：NCBI_Gene: 3952
  • 蛋白序列：UniProtKB: P41159

人 Human LEP靶点分子功能（预测）

Enables leptin receptor binding activity. Involved in several processes, including positive regulation of signal transduction; regulation of cytokine production; and regulation of lymphocyte proliferation. Predicted to be located in cytosol. Predicted to be active in extracellular space. Implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including alcohol dependence; cystic fibrosis; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).

小鼠 Mouse Lep 分子靶点信息

小鼠 Mouse Lep 靶点分子功能（预测）

Enables DNA binding activity and growth factor activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including insulin secretion; monocarboxylic acid metabolic process; and regulation of insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple); fatty liver disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin).

大鼠 Rat Lep 分子靶点信息

大鼠 Rat Lep 靶点分子功能（预测）

Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and response to vitamin. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington's disease; alcohol dependence; fatty liver disease (multiple); lipid metabolism disorder (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (leptin).

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