Human TLR2 Standard (人Toll样受体2 (TLR2) 标准品)

TLR2 分子靶点信息概述

• 分子名：TLR2, toll like receptor 2
• 基因家族：CD molecules; Toll like receptors
• 别名：TIL4; CD282
• 全称：toll-like receptor 2

TLR2 分子靶点综述

Toll样受体2（TLR2）是一种跨膜受体，可在多种细胞类型（包括小胶质细胞，单核细胞，巨噬细胞和树突状细胞）中表达。TLR组成了模式识别受体家族，在先天免疫反应中起着重要作用。。大量的病原体（例如病毒，细菌和真菌）组成性地表达了一套称为病原体相关分子模式（PAMP）的抗突变分子。这些微生物分子标记物可以由蛋白质，碳水化合物，脂质，核酸和/或其组合组成。单个TLR识别不同的病原体相关PAMP，启动信号级联反应，从而促进免疫反应。

人 Human TLR2 分子靶点信息

• 分子名：TLR2, toll like receptor 2
• 别称：
  • CD282
  • TIL4
  • toll-like receptor 2
  • toll/interleukin 1 receptor-like 4
  • toll/interleukin-1 receptor-like protein 4
• 基因序列：NCBI_Gene: 7097
• 蛋白序列：UniProtKB: O60603

人 Human TLR2靶点分子功能（预测）

Enables several functions, including lipopolysaccharide binding activity; peptide binding activity; and peptidoglycan binding activity. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity and response to molecule of bacterial origin. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Is intrinsic component of plasma membrane. Part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Is integral component of plasma membrane. Implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); middle ear disease (multiple); and nose disease (multiple).