Human Thrombospondin-1/THBS-1 Standard (人血小板反应素-1 (THBS-1) 标准品)

THBS1 分子靶点信息概述

• 分子名：THBS1, thrombospondin 1
• 别名：TSP1; THBS; TSP; THBS-1; TSP-1
• 全称：thrombospondin-1p180

THBS1 分子靶点综述

血小板反应素-1(THBS-1)是血小板反应素家族成员，介导细胞-细胞和细胞-基质相互作用。该蛋白可与纤维蛋白原、纤维连接蛋白、层粘连蛋白、V型胶原和整合素α-V/β-1结合。它对血小板聚集、血管生成和肿瘤发生发挥作用。在正常组织中，它是新血管形成和肿瘤发生的天然抑制剂。THBS-1还可正向和负向调控内皮细胞黏附、运动和生长。通过阻断THBS-1与细胞表面受体(CD47)结合，正常组织几乎对肿瘤辐射治疗产生免疫，并有助肿瘤死亡。

人 Human THBS1 分子靶点信息

• 分子名：THBS1, thrombospondin 1
• 别称：
  • glycoprotein G
  • THBS
  • THBS-1
  • thrombospondin-1
  • thrombospondin-1p180
  • thrombospondin-p50
  • TSP
  • TSP-1
  • TSP1
• 基因序列：NCBI_Gene: 7057
• 蛋白序列：UniProtKB: P07996

人 Human THBS1靶点分子功能（预测）

Enables several functions, including collagen V binding activity; fibrinogen binding activity; and fibroblast growth factor binding activity. Involved in several processes, including regulation of cell migration; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of endothelial cell chemotaxis; negative regulation of endothelial cell proliferation; and negative regulation of nitric oxide mediated signal transduction. Located in several cellular components, including external side of plasma membrane; extracellular space; and platelet alpha granule. Part of fibrinogen complex. Colocalizes with collagen-containing extracellular matrix. Implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Biomarker of COVID-19; cholangiocarcinoma; obesity; pancreatic cancer (multiple); and urinary bladder cancer.