Human sE-Selectin Standard (人可溶性E选择素 标准品)

SELE 分子靶点信息概述

• 分子名：SELE, selectin E
• 基因家族：CD molecules; Selectins; Sushi domain containing; C-type lectin domain containing
• 别名：ESEL; CD62E
• 曾用名：ELAM1; ELAM
• 全称：endothelial adhesion molecule 1

SELE 分子靶点综述

E-选择素，又名CD62E、内皮-白细胞粘附分子1(ELAM-1)或者白细胞-内皮细胞粘附分子2(LECAM2)，是一个115kDa的糖蛋白，只有被炎性细胞因子(IL-1β或TNF-α)或内皮细胞中的内毒素激活后才表达。细胞表面的E-选择素介导白细胞附着到内皮，从而在局部炎症反应中起重要作用。E-选择素的胞外区包括一个钙依赖性的C2型凝集素结构域、一个表皮生长因子(EGF)结构域和6个重复的补体调节蛋白样序列。可溶性E-选择素(sE-Selectin)存在于健康机体的血液中，可能产生于表面表达分子的蛋白裂解。监测血清中sE-Selectin水平可为一些病理情况如癌症、感染性疾病、糖尿病和脓毒病提供更详细的见解。

人 Human SELE 分子靶点信息

• 分子名：SELE, selectin E
• 别称：
  • CD62 antigen-like family member E
  • CD62E
  • E-selectin
  • ELAM
  • ELAM-1
  • ELAM1
  • endothelial adhesion molecule 1
  • endothelial leukocyte adhesion molecule 1
  • ESEL
  • LECAM2
  • leukocyte endothelial cell adhesion molecule 2
  • leukocyte-endothelial cell adhesion molecule 2
• 基因序列：NCBI_Gene: 6401
• 蛋白序列：UniProtKB: P16581

人 Human SELE靶点分子功能（预测）

Enables several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in several processes, including activation of phospholipase C activity; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and leukocyte tethering or rolling. Located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Biomarker of COVID-19; rheumatic myocarditis; and type 1 diabetes mellitus.