SELE 靶点信息

SELE 分子靶点信息概述

  • 分子名：SELE, selectin E
  • 基因家族：CD molecules; Selectins; Sushi domain containing; C-type lectin domain containing
  • 别名：ESEL; CD62E
  • 曾用名：ELAM1; ELAM
  • 全称：endothelial adhesion molecule 1

SELE 分子靶点综述

E-选择素，又名CD62E、内皮-白细胞粘附分子1(ELAM-1)或者白细胞-内皮细胞粘附分子2(LECAM2)，是一个115kDa的糖蛋白，只有被炎性细胞因子(IL-1β或TNF-α)或内皮细胞中的内毒素激活后才表达。细胞表面的E-选择素介导白细胞附着到内皮，从而在局部炎症反应中起重要作用。E-选择素的胞外区包括一个钙依赖性的C2型凝集素结构域、一个表皮生长因子(EGF)结构域和6个重复的补体调节蛋白样序列。可溶性E-选择素(sE-Selectin)存在于健康机体的血液中，可能产生于表面表达分子的蛋白裂解。监测血清中sE-Selectin水平可为一些病理情况如癌症、感染性疾病、糖尿病和脓毒病提供更详细的见解。

SELE, selectin E 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human SELE 分子靶点信息

  • 分子名：SELE, selectin E
  • 别称：
    • CD62 antigen-like family member E
    • CD62E
    • E-selectin
    • ELAM
    • ELAM-1
    • ELAM1
    • endothelial adhesion molecule 1
    • endothelial leukocyte adhesion molecule 1
    • ESEL
    • LECAM2
    • leukocyte endothelial cell adhesion molecule 2
    • leukocyte-endothelial cell adhesion molecule 2
  • 基因序列：NCBI_Gene: 6401
  • 蛋白序列：UniProtKB: P16581

人 Human SELE靶点分子功能（预测）

Enables several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in several processes, including activation of phospholipase C activity; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and leukocyte tethering or rolling. Located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Biomarker of COVID-19; rheumatic myocarditis; and type 1 diabetes mellitus.

小鼠 Mouse Sele 分子靶点信息

小鼠 Mouse Sele 靶点分子功能（预测）

Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within positive regulation of leukocyte migration. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including adrenal gland; genitourinary system; incisor; integumental system; and limb segment. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E).

大鼠 Rat Sele 分子靶点信息

  • 分子名：Sele, selectin E
  • 别称：
    • CD62 antigen-like family member E
    • E-selectin
    • ELAM-1
    • endothelial leukocyte adhesion molecule 1
    • LECAM2
    • leukocyte-endothelial cell adhesion molecule 2
    • selectin, endothelial cell
  • 基因序列：NCBI_Gene: 25544
  • 蛋白序列：

大鼠 Rat Sele 靶点分子功能（预测）

Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in inflammatory response; leukocyte migration; and response to cytokine. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E).

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