SERPINE1 靶点信息

SERPINE1 分子靶点信息概述

  • 分子名：SERPINE1, serpin family E member 1
  • 基因家族：Serpin peptidase inhibitors
  • 别名：PAI
  • 曾用名：PLANH1; PAI1
  • 全称：plasminogen activator inhibitor, type I; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

SERPINE1 分子靶点综述

Serpin E1，又名纤溶酶原激活物抑制因子-1 (PAI-1)，是丝氨酸蛋白酶抑制剂超家族中的一员，主要由内皮(血管内皮衬里细胞)产生，但也由其他类型的组织如脂肪组织分泌产生。Serpin E1是尿激酶和组织型纤溶酶原激活剂(uPA和tPA)的主要抑制剂。PA-血纤维蛋白溶酶系统参与多种生理和病理过程如纤维蛋白溶解、纤维化、血管生成、伤口愈合、肿瘤细胞的侵袭和转移。例如，高水平的uPA和Serpin E1与乳腺癌患者的预后不良相关，研究证实uPA和Serpin E1的临床价值处于1级水平，是最可靠的生物标志物。除了乳腺癌，Serpin E1也参与许多其它疾病如代谢综合征、哮喘、重度抑郁症(MDD)以及衰老相关疾病。血浆中Serpin E1的缺失将导致异常出血，高水平的Serpin E1与遗传性易栓症相关。

SERPINE1, serpin family E member 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human SERPINE1 分子靶点信息

  • 分子名：SERPINE1, serpin family E member 1
  • 别称：
    • endothelial plasminogen activator inhibitor
    • PAI
    • PAI-1
    • PAI1
    • PLANH1
    • plasminogen activator inhibitor 1
    • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    • serpin E1
    • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • 基因序列：NCBI_Gene: 5054
  • 蛋白序列：UniProtKB: P05121

人 Human SERPINE1靶点分子功能（预测）

Enables protease binding activity; serine-type endopeptidase inhibitor activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of proteolysis; regulation of angiogenesis; and response to bacterium. Located in collagen-containing extracellular matrix and extracellular exosome. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); lung disease (multiple); and sleep apnea (multiple).

小鼠 Mouse Serpine1 分子靶点信息

小鼠 Mouse Serpine1 靶点分子功能（预测）

Enables serine-type endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium; negative regulation of plasminogen activation; and regulation of angiogenesis. Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; placenta development; and regulation of angiogenesis. Located in extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).

大鼠 Rat Serpine1 分子靶点信息

  • 分子名：Serpine1, serpin family E member 1
  • 别称：
    • endothelial plasminogen activator inhibitor
    • PAI
    • PAI-1
    • Pai1
    • PAI1A
    • Pai1aa
    • Planh
    • Plasminogen activator inhibitor
    • plasminogen activator inhibitor 1
    • RATPAI1A
    • serine (or cysteine) peptidase inhibitor, clade E, member 1
    • serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1
    • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    • serine (or cysteine) proteinase inhibitor, clade E, member 1
    • serine (or cysteine) proteinase inhibitor, member 1
    • serpin E1
    • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
  • 基因序列：NCBI_Gene: 24617
  • 蛋白序列：

大鼠 Rat Serpine1 靶点分子功能（预测）

Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).

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