EK1264S

Human CXCL2/GRO-β Standard (人生长调节致癌基因β 标准品)

¥280.00

  • 分子靶点:CXCL2, MIP-2a, GRO2, GROb
  • 种属:人 (Human)
  • 试剂盒:EK1264
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK1264S


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商品名

Human CXCL2/GRO-β Standard (人生长调节致癌基因β 标准品)

组分

人 CXCL2/GRO-β 标准品

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

分子信息

概述人 CXCL2, MIP-2a, GRO2, GROb 靶点信息

CXCL2 分子靶点信息概述

  • 分子名:CXCL2, C-X-C motif chemokine ligand 2
  • 基因家族:Chemokine ligands
  • 别名:SCYB2; GROb; MIP-2a; MGSA-b; CINC-2a
  • 曾用名:GRO2
  • 全称:GRO2 oncogene; chemokine (C-X-C motif) ligand 2

CXCL2 分子靶点综述

人生长调节致癌基因β (GRO-β)也称为 CXCL2,是 CXC 蛋白趋化因子家族成员之一。GRO-β 在小鼠中也称为 MIP-2,在大鼠中称为 CINC-3。人 GRO-β由 107 个氨基酸(aa)构成,其分子量约 为 11 kDa。GRO-β是由炎症部位的多种细胞(包括单核细胞和巨噬细胞)分泌,对粒细胞包括中性粒 细胞具有趋化作用。GRO-β在炎症反应和损伤修复过程中起着重要作用。研究逐渐发现 GRO 为一种原癌基因。GRO-β作为表达产物在血管新生、肿瘤形成转移和肿瘤与免疫细胞相互作用中起到关键作用。

人 Human CXCL2 分子靶点信息

  • 分子名:CXCL2, C-X-C motif chemokine ligand 2
  • 别称:
    • C-X-C motif chemokine 2
    • chemokine (C-X-C motif) ligand 2
    • CINC-2a
    • gro-beta
    • GRO2
    • GRO2 oncogene
    • GROb
    • growth-regulated protein beta
    • macrophage inflammatory protein 2-alpha
    • melanoma growth stimulatory activity beta
    • MGSA beta
    • MGSA-b
    • MIP-2a
    • MIP2
    • MIP2-alpha
    • MIP2A
    • SCYB2
  • 基因序列:NCBI_Gene: 2920
  • 蛋白序列:UniProtKB: P19875

人 Human CXCL2靶点分子功能(预测)

Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; and response to molecule of bacterial origin. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of COVID-19 and cystic fibrosis.

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引用文献

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  1. Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet’s disease 

  2. Alteration of Myeloid-Derived Suppressor Cells, Chronic Inflammatory Cytokines, and Exosomal miRNA Contribute to the Peritoneal Immune Disorder of Patients With Endometriosis 

  3. Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity 

  4. PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR+ CXC chemokine expression 

  5. Hypoxia-CXCL6 axis affects arteriolar niche remodeling in acute myeloid leukemia. 

  6. Cancer-associated adipocytes promote the invasion and metastasis in breast cancer through LIF/CXCLs positive feedback loop 

  7. Cisplatin-stimulated macrophages promote ovarian cancer migration via the CCL20-CCR6 axis 

  8. Deciphering m6A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy 

  9. The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression 

  10. Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D 

  11. Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions 

  12. An inflammatory checkpoint generated by IL1RN splicing offers therapeutic opportunity for KRAS mutant intrahepatic cholangiocarcinoma 

  13. CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway