Human CXCL5/ENA-78 Standard (人趋化因子CXC配体5/上皮来源的中性粒细胞激活肽78 标准品)

CXCL5 分子靶点信息概述

• 分子名：CXCL5, C-X-C motif chemokine ligand 5
• 基因家族：Chemokine ligands
• 别名：ENA-78
• 曾用名：SCYB5
• 全称：small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78); chemokine (C-X-C motif) ligand 5

CXCL5 分子靶点综述

C-X-C基序趋化因子5(CXCL5)，又名上皮来源的中性粒细胞激活肽78(ENA-78)，是CXC趋化因子家族中的小分子量细胞因子。炎性细胞因子IL-1或TNF-α刺激细胞后可产生CXCL5，嗜酸性细胞也可表达CXCL5，而II型干扰素IFN-γ可抑制其表达。CXCL5通过与细胞表面趋化因子受体CXCR2相互作用来发挥其作用效果，可刺激具有血管生成特性的中性粒细胞的趋化性，并参与结缔组织重塑。CXCL5同样具有调节中性粒细胞稳态的作用。CXCL5在动脉粥样硬化(一种慢性炎症状态)中表达较高，但与中性粒细胞的浸润无关。相反，CXCL5可直接控制巨噬细胞的泡沫细胞形成，从而对动脉粥样硬化起保护作用。

人 Human CXCL5 分子靶点信息

• 分子名：CXCL5, C-X-C motif chemokine ligand 5
• 别称：
  • C-X-C motif chemokine 5
  • chemokine (C-X-C motif) ligand 5
  • ENA-78
  • ENA-78(1-78)
  • epithelial-derived neutrophil activating protein 78
  • epithelial-derived neutrophil-activating peptide 78
  • epithelial-derived neutrophil-activating protein 78
  • neutrophil-activating peptide ENA-78
  • neutrophil-activating protein 78
  • SCYB5
  • small inducible cytokine B5
  • small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)
  • small-inducible cytokine B5
• 基因序列：NCBI_Gene: 6374
• 蛋白序列：UniProtKB: P42830

人 Human CXCL5靶点分子功能（预测）

Enables identical protein binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; and neutrophil chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in idiopathic pulmonary fibrosis. Biomarker of several diseases, including common cold; diffuse scleroderma; hyperhomocysteinemia; lung disease (multiple); and sinusitis.