CXCL5 靶点信息

CXCL5 分子靶点信息概述

  • 分子名：CXCL5, C-X-C motif chemokine ligand 5
  • 基因家族：Chemokine ligands
  • 别名：ENA-78
  • 曾用名：SCYB5
  • 全称：small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78); chemokine (C-X-C motif) ligand 5

CXCL5 分子靶点综述

C-X-C基序趋化因子5(CXCL5)，又名上皮来源的中性粒细胞激活肽78(ENA-78)，是CXC趋化因子家族中的小分子量细胞因子。炎性细胞因子IL-1或TNF-α刺激细胞后可产生CXCL5，嗜酸性细胞也可表达CXCL5，而II型干扰素IFN-γ可抑制其表达。CXCL5通过与细胞表面趋化因子受体CXCR2相互作用来发挥其作用效果，可刺激具有血管生成特性的中性粒细胞的趋化性，并参与结缔组织重塑。CXCL5同样具有调节中性粒细胞稳态的作用。CXCL5在动脉粥样硬化(一种慢性炎症状态)中表达较高，但与中性粒细胞的浸润无关。相反，CXCL5可直接控制巨噬细胞的泡沫细胞形成，从而对动脉粥样硬化起保护作用。

CXCL5, C-X-C motif chemokine ligand 5 分子靶点种属信息

人 Human小鼠 Mouse

人 Human CXCL5 分子靶点信息

  • 分子名：CXCL5, C-X-C motif chemokine ligand 5
  • 别称：
    • C-X-C motif chemokine 5
    • chemokine (C-X-C motif) ligand 5
    • ENA-78
    • ENA-78(1-78)
    • epithelial-derived neutrophil activating protein 78
    • epithelial-derived neutrophil-activating peptide 78
    • epithelial-derived neutrophil-activating protein 78
    • neutrophil-activating peptide ENA-78
    • neutrophil-activating protein 78
    • SCYB5
    • small inducible cytokine B5
    • small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)
    • small-inducible cytokine B5
  • 基因序列：NCBI_Gene: 6374
  • 蛋白序列：UniProtKB: P42830

人 Human CXCL5靶点分子功能（预测）

Enables identical protein binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; and neutrophil chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in idiopathic pulmonary fibrosis. Biomarker of several diseases, including common cold; diffuse scleroderma; hyperhomocysteinemia; lung disease (multiple); and sinusitis.

小鼠 Mouse Cxcl5 分子靶点信息

  • 分子名：Cxcl5, chemokine (C-X-C motif) ligand 5
  • 别称：
    • AMCF-II
    • Cxcl6
    • ENA-78
    • GCP-2
    • granulocyte chemotactic protein-2
    • LIX
    • Scyb5
    • Scyb6
    • small inducible cytokine B subfamily, member 5
    • small inducible cytokine subfamily B, member 15
  • 基因序列：NCBI_Gene: 20311
  • 蛋白序列：

小鼠 Mouse Cxcl5 靶点分子功能（预测）

Predicted to enable CXCR chemokine receptor binding activity; chemokine activity; and identical protein binding activity. Acts upstream of or within several processes, including leukocyte homeostasis; regulation of neutrophil mediated killing of gram-negative bacterium; and response to lipopolysaccharide. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system; liver lobe; molar; and sensory organ. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to several human genes including CXCL6 (C-X-C motif chemokine ligand 6).

CXCL5 分子产品列表

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