Human IL-8 High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
¥2,000.00 – ¥3,400.00
在售SKU:70-EK108HS-48, 70-EK108HS-96, 人白细胞介素8, 白细胞介素8, 白细胞介素, 人, 白介素, 8
- 分子靶点:CXCL8
- 种属:人
- 样本类型:血清、血浆、细胞培养上清及其他生物学样本
- 检测样本体积:血清血浆:50μL;细胞培养上清:100μL
- 灵敏度:1.13pg/mL
- 检测范围:2.34-150pg/mL
- 回收率:90%-103%
ELISA试剂盒详细信息
商品名 | 人 IL-8高敏酶联免疫检测试剂盒 |
---|---|
种属 | 人 |
靶点 | CXCL8 |
检测方法 | 双抗体夹心法 |
检测样本类型 | 血清、血浆、细胞培养上清及其他生物学样本 |
检测样本体积 | 血清血浆:50μL;细胞培养上清:100μL |
灵敏度 | 1.13pg/mL |
线性范围 | 2.34-150pg/mL |
精密度 | 板内变异系数:6.9%-9.6%;板间变异系数:3.2%-7.0% |
回收率 | 90%-103% |
平均回收率 | 97% |
板式 | 96孔板,可拆 |
保存条件 | 2-8℃保存。已拆开:标准品-20℃保存,其它4℃。 |
运输条件 | 2-8℃冰袋运输 |
检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IL-8抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本,经过孵育,样本中存在的IL-8与固相抗体结合。洗涤去除未结合的物质后,加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入信号增强剂孵育,洗涤去除未结合的物质后,再次加入Streptavidin-HRP。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中IL-8的浓度成正比。加入终止液终止反应,在450nm波长(参考波长570 - 630nm)测定吸光度值。 |
分子信息
CXCL8 分子靶点信息概述
- 分子名:CXCL8, C-X-C motif chemokine ligand 8
- 基因家族:Chemokine ligands; Interleukins
- 别名:SCYB8; LUCT; LECT; MDNCF; TSG-1; IL-8; NAP-1; 3-10C; MONAP; AMCF-I; LYNAP; NAF; b-ENAP; GCP-1; K60; GCP1; NAP1
- 曾用名:IL8
- 全称:neutrophil-activating peptide 1; granulocyte chemotactic protein 1; monocyte-derived neutrophil chemotactic factor; lung giant cell carcinoma-derived chemotactic protein; tumor necrosis factor-induced gene 1; monocyte-derived neutrophil-activating peptide; lymphocyte derived neutrophil activating peptide; beta endothelial cell-derived neutrophil activating peptide; alveolar macrophage chemotactic factor I; interleukin 8; chemokine (C-X-C motif) ligand 8
CXCL8 分子靶点综述
白细胞介素8(IL-8)是由巨噬细胞和其它类型细胞如上皮细胞、气道平滑肌细胞和内皮细胞产生的趋化因子,在人类中,由IL8基因编码。IL-8可有效促进血管生成,在细支气管炎的发病机制中起重要作用。IL-8可通过对中性粒细胞的召集和脱颗粒来实现对炎症反应的调节,可作为结肠癌细胞株的自分泌生长因子来作用于结肠直肠癌。高水平的IL-8可减少精神分裂症患者抗精神病药的阳性反应。另外,IL-8与肥胖和囊性纤维化的发病机制也相关。
人 Human CXCL8 分子靶点信息
- 分子名:CXCL8, C-X-C motif chemokine ligand 8
- 别称:
- alveolar macrophage chemotactic factor I
- beta endothelial cell-derived neutrophil activating peptide
- beta-thromboglobulin-like protein
- C-X-C motif chemokine 8
- chemokine (C-X-C motif) ligand 8
- emoctakin
- GCP-1
- GCP1
- granulocyte chemotactic protein 1
- IL8
- interleukin 8
- interleukin-8
- LECT
- LUCT
- lung giant cell carcinoma-derived chemotactic protein
- lymphocyte derived neutrophil activating peptide
- lymphocyte-derived neutrophil-activating factor
- LYNAP
- MDNCF
- MONAP
- monocyte-derived neutrophil chemotactic factor
- monocyte-derived neutrophil-activating peptide
- NAF
- NAP-1
- NAP1
- neutrophil-activating peptide 1
- SCYB8
- small inducible cytokine subfamily B, member 8
- T cell chemotactic factor
- T-cell chemotactic factor
- tumor necrosis factor-induced gene 1
- 基因序列:NCBI_Gene: 3576
- 蛋白序列:UniProtKB: P10145
人 Human CXCL8靶点分子功能(预测)
Enables chemokine activity and interleukin-8 receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; induction of positive chemotaxis; and neutrophil chemotaxis. Acts upstream of or within negative regulation of cell adhesion molecule production; positive regulation of cellular biosynthetic process; and regulation of gene expression. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including autoimmune uveitis; bacterial gastritis; gastrointestinal system cancer (multiple); trachoma; and urinary tract infection. Biomarker of several diseases, including chikungunya; cholestasis (multiple); cystic fibrosis; liver disease (multiple); and tuberculosis (multiple).
引用文献统计
该产品被引用的文献总数为:82
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