P280

Recombinant Mouse IFN-gamma

¥400.00 – ¥1,300.00

说明书

分子靶点：IFNG, IFN-γ
种属：小鼠 (Mouse)
表达宿主：Escherichia coli
纯度：≥95% as determined by SDS-PAGE
内毒素：<1EU/ug

在售SKU: P280, 70-P280-10, 70-P280-100, 70-P280-20, 70-P280-50

文章目录[隐藏]

General Information
Specifications
Data
分子信息
IFNG 分子靶点信息概述
IFNG 分子靶点综述
- 小鼠 Mouse Ifng 分子靶点信息
- 小鼠 Mouse Ifng 靶点分子功能（预测）

General Information

Source	Escherichia coli
Synonyms	IFN-γ, Immune Interferon, type II interferon, T cell interferon, MAF
Accession	P01580
Molecular Mass	15.6 KDa
Description	Recombinant Mouse IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.
Shipping	The product is shipped at 4 ℃ . Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Aliquot the reconstituted solution to minimize freeze-thaw cycles. Lyophilized protein should be stored at -20℃ to -80℃, stable for one year after receipt. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Reconstitution	Centrifuge tubes before opening. Dissolve the lyophilized protein in distilled water. Do not mix by vortex. It is recommended to dissolve the product at a concentration of twice the specified specification.
Background	IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes, as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN- γ signaling in antigen-presenting, cells and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN- γ is species-specific and is biologically active only in human and primate cells.

Specifications

Formulation	Lyophilized from sterile PBS, pH 7.4, 5% trehalose.
Purity	≥95% as determined by SDS-PAGE
Endotoxin	< 1EU/ug
Bio Activity	Recombinant Mouse IFN-γ can be detected by ELISA with a linear range of 23 - 1,500 pg/mL.

Data

Greater than 95% as determined by reducing SDS-PAGE.

Bioactivity — Recombinant Mouse IFN-γ can be detected by ELISA with a linear range of 23 - 1,500 pg/mL.

分子信息

概述小鼠 IFNG, IFN-γ 靶点信息

IFNG 分子靶点信息概述

分子名：IFNG, interferon gamma
基因家族：Interferons

IFNG 分子靶点综述

IFN-γ主要由Th1型细胞产生，属于II型细胞因子中干扰素家族中的一员，是一类分泌型糖蛋白，由143个氨基酸组成，相对分子质量是16942。IFN-γ主要由活化的T细胞和NK细胞产生，具有调节机体免疫状态，介导细胞免疫，加强受体介导的吞噬功能，增强巨噬细胞和中性粒细胞的杀伤活性，具有抗病毒感染及抗肿瘤等生物学活性。

小鼠 Mouse Ifng 分子靶点信息

分子名：Ifng, interferon gamma
别称：
- Ifg
- IFN-gamma
基因序列：NCBI_Gene: 15978
蛋白序列：

小鼠 Mouse Ifng 靶点分子功能（预测）

Enables cytokine activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and regulation of generation of precursor metabolites and energy. Acts upstream of or within several processes, including CD8-positive, alpha-beta T cell differentiation involved in immune response; defense response to other organism; and positive regulation of macromolecule metabolic process. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Used to study several diseases, including aplastic anemia; hepatitis; malaria; medulloblastoma; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; ataxia telangiectasia; autoimmune disease (multiple); eczema herpeticum; and leukemia (multiple). Orthologous to human IFNG (interferon gamma).