Rat JE/MCP-1/CCL2 Standard (大鼠 JE/MCP-1/CCL2 标准品)

CCL2 分子靶点信息概述

• 分子名：CCL2, C-C motif chemokine ligand 2
• 基因家族：Chemokine ligands
• 别名：MCP1; MCP-1; MCAF; SMC-CF; GDCF-2; HC11; MGC9434
• 曾用名：SCYA2
• 全称：monocyte chemotactic protein 1, homologous to mouse Sig-je; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte secretory protein JE; small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); chemokine (C-C motif) ligand 2

CCL2 分子靶点综述

趋化因子配体2(CCL2)，又名单核细胞趋化蛋白1(MCP-1)，是CC趋化因子家族的小分子量细胞因子。CCL2通过蛋白聚糖的粘多糖侧链锚定到内皮细胞的质膜上，主要由单核细胞、巨噬细胞和树突状细胞分泌。CCL2可招募单核细胞、记忆性T细胞和树突状细胞到组织损伤或感染引起的炎症位点。CCL2参与以单核细胞浸润为特征的一些疾病发病机制，如银屑病、类风湿性关节炎和动脉粥样硬化。CCL2参与发生在中枢神经系统的多种疾病的神经炎症过程，表现为神经元变性。

大鼠 Rat Ccl2 分子靶点信息

• 分子名：Ccl2, C-C motif chemokine ligand 2
• 别称：
  • C-C motif chemokine 2
  • chemokine (C-C motif) ligand 2
  • immediate-early serum-responsive JE protein
  • immediate-early serum-responsive protein JE
  • MCP-1
  • monocyte chemoattractant protein 1
  • monocyte chemoattractant protein-1
  • monocyte chemotactic protein 1
  • Scya2
  • Sigje
  • small inducible cytokine A2
  • Small inducible gene JE
  • small-inducible cytokine A2
• 基因序列：NCBI_Gene: 24770
• 蛋白序列：UniProtKB: P14844

大鼠 Rat Ccl2 靶点分子功能（预测）

Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and leukocyte migration. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Colocalizes with C-fiber. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); lung disease (multiple); non-alcoholic fatty liver disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and tuberculosis (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2).