Mouse SCF Standard (小鼠干细胞因子 (SCF) 标准品)

KITLG 分子靶点信息概述

• 分子名：KITLG, KIT ligand
• 别名：SCF; SF; Kitl; KL-1; FPH2; SLF; DFNA69
• 曾用名：MGF
• 全称：mast cell growth factor; stem cell factor; steel factor; familial progressive hyperpigmentation 2

KITLG 分子靶点综述

干细胞因子(SCF)是一个可结合到c-Kit受体上的细胞因子，它可作为跨膜蛋白和可溶性蛋白存在。SCF促进肥大细胞粘附、迁移、增殖和存活，同样也可促进组胺和类胰蛋白酶的释放，后两者参与过敏应答。SCF与多种生长因子如IL-3、IL-6、IL-11、GM-CSF、G-CSF和Epo协同作用，一起诱导髓系和红系集落形成。该细胞因子在造血(血细胞生成)、精子发生和黑素生成中起重要作用。心肌特异性过表达跨膜SCF会促进干细胞迁移、提高心肌梗死后的心脏功能和动物的存活率。狗的SCF基因突变表明该基因是皮肤癌的候选易感基因。

小鼠 Mouse Kitl 分子靶点信息

• 分子名：Kitl, kit ligand
• 别称：
  • blaze
  • blz
  • Clo
  • cloud gray
  • Con
  • contrasted
  • Gb
  • grizzle-belly
  • Kitlg
  • mast cell growth factor
  • Mgf
  • SCF
  • SF
  • Sl
  • SLF
  • steel
  • Steel
  • Steel factor
  • stem cell factor
• 基因序列：NCBI_Gene: 17311
• 蛋白序列：
  • UniprotKB: P20826
  • UniprotKB: A0A1W2P773
  • UniprotKB: Q61854
  • UniprotKB: Q78ED8
  • UniprotKB: Q8C9K1

小鼠 Mouse Kitl 靶点分子功能（预测）

Enables cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in extracellular space and plasma membrane. Is integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand).