Mouse IL-18 Standard (小鼠白细胞介素18 标准品)

IL18 分子靶点信息概述

• 分子名：IL18, interleukin 18
• 基因家族：Interleukins
• 别名：IGIF; IL1F4; IL-1g; IL-18
• 全称：interferon-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor)

IL18 分子靶点综述

白细胞介素18(IL-18)，又名干扰素γ诱导因子，是一种促炎性细胞因子，在人类中由IL18基因编码。IL-18属于IL-1超家族，由巨噬细胞和其它细胞分泌产生。IL-18刺激后，自然杀伤细胞(NK)和某些T细胞就会释放另一种重要的细胞因子—干扰素γ或Ⅱ型干扰素，进而激活巨噬细胞或其它细胞。IL-18可诱导产生严重的炎症反应，同样可增加人类神经元中β-淀粉样蛋白(与阿尔茨海默氏病相关)的产生。

小鼠 Mouse Il18 分子靶点信息

• 分子名：Il18, interleukin 18
• 别称：
  • Igif
  • Il-18
  • interferon gamma inducing factor
• 基因序列：NCBI_Gene: 16173
• 蛋白序列：
  • UniprotKB: P70380
  • UniprotKB: A0A1L1STF5
  • UniprotKB: A0PJ18
  • UniprotKB: K3W4N2
  • UniprotKB: Q2PMY2
  • UniprotKB: Q6USQ6
  • UniprotKB: Q80SS8

小鼠 Mouse Il18 靶点分子功能（预测）

Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).