Mouse HGF Standard (小鼠HGF 标准品)

SOS1 分子靶点信息概述

• 分子名：SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
• 基因家族：Pleckstrin homology domain containing; Dbl family Rho GEFs
• 别名：HGF; GF1
• 曾用名：GINGF
• 全称：gingival fibromatosis, hereditary, 1; son of sevenless homolog 1 (Drosophila)

SOS1 分子靶点综述

肝细胞生长因子（HGF），也称为分散因子，肝细胞生成素A和乳腺生长因子，是一种多效糖蛋白，可调节多种细胞类型的生长和迁移。HGF以全长无活性多肽的形式分泌，然后被丝氨酸蛋白酶切割成60 kDa N端α链和30 kDa C端β链的活性异二聚体分子。HGF由成纤维细胞，脂肪细胞，平滑肌细胞和内皮细胞表达。HGF的血清水平在多种病理中均升高，包括肝损伤，急性肾衰竭，心肌梗塞，1型糖尿病，肥胖症和癌症，以及类风湿关节炎患者的关节液中。

小鼠 Mouse Sos1 分子靶点信息

• 分子名：Sos1, SOS Ras/Rac guanine nucleotide exchange factor 1
• 别称：
  • AI573415
  • expressed sequence AI573415
  • Sfpd
  • Sftp4
  • SP-D
  • surfactant-associated protein 4
• 基因序列：NCBI_Gene: 20662
• 蛋白序列：
  • UniprotKB: Q62245
  • UniprotKB: Q3USK4

小鼠 Mouse Sos1 靶点分子功能（预测）

Enables identical protein binding activity. Predicted to be involved in several processes, including induction of bacterial agglutination; negative regulation of interleukin-2 production; and regulation of phagocytosis. Predicted to act upstream of or within innate immune response and respiratory gaseous exchange by respiratory system. Located in cytoplasm. Is expressed in lung; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).