Human sVCAM-1/CD106 Standard (人血管细胞粘附分子1 (VCAM-1) 标准品)

VCAM1 分子靶点信息概述

• 分子名：VCAM1, vascular cell adhesion molecule 1
• 基因家族：CD molecules; Receptor ligands; C2-set domain containing; I-set domain containing; Ig-like cell adhesion molecule family
• 别名：CD106

VCAM1 分子靶点综述

血管细胞粘附分子1(VCAM-1)也称为CD106，是100-110kDaI型跨膜蛋白，通常具有7个C2型免疫球蛋白结构域，作为细胞黏附分子发挥功能。VCAM-1蛋白介导淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞等黏附于血管内皮。VCAM-1是整合素β1亚家族VLA-4(极迟抗原-4或α4β1)和整合素α4β7的内皮配体。在其他类型细胞上也观察到VCAM-1的表达。它也能与EZR和膜突蛋白作用。VCAM-1的其它功能包括通过细胞-细胞接触调控破骨细胞生成、血氧不足时诱导镰状细胞黏附于血管内皮细胞。它还在白细胞-内皮细胞信号传导中发挥作用。监测血清中的sVCAM-1表达水平可为多种病理状态提供更详细的视角，如动脉粥样硬化和类风湿性关节炎。

人 Human VCAM1 分子靶点信息

• 分子名：VCAM1, vascular cell adhesion molecule 1
• 别称：
  • CD106
  • CD106 antigen
  • DKFZp779G2333
  • INCAM-100
  • MGC99561
  • vascular cell adhesion protein 1
• 基因序列：NCBI_Gene: 7412
• 蛋白序列：UniProtKB: P19320

人 Human VCAM1靶点分子功能（预测）

Enables integrin binding activity and primary amine oxidase activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cell-cell adhesion in response to extracellular stimulus; and cellular response to amyloid-beta. Located in several cellular components, including early endosome; external side of plasma membrane; and podosome. Part of alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); essential thrombocythemia; glomerulonephritis (multiple); and interstitial cystitis.