EK1109

Human sTNF RI/TNFRSF1A ELISA Kit检测试剂盒(酶联免疫吸附法)

¥1,600.00¥2,650.00

在售SKU:70-EK1109-48, 70-EK1109-96, EK1109, 人, 可溶性, 肿瘤, 坏死, 因子, 受体, 1

  • 分子靶点:TNFRSF1A
  • 种属:
  • 样本类型:血清、血浆、细胞培养上清及其他生物学样本
  • 检测样本体积:血清、血浆样本10μL
  • 灵敏度:0.08pg/mL
  • 检测范围:7.81-500pg/mL
  • 回收率:93%-109%

ELISA试剂盒详细信息

商品名人可溶性肿瘤坏死因子受体1酶联免疫检测试剂盒
种属
靶点TNFRSF1A
检测方法双抗体夹心法
检测样本类型血清、血浆、细胞培养上清及其他生物学样本
检测样本体积血清、血浆样本10μL
灵敏度0.08pg/mL
线性范围7.81-500pg/mL
精密度板内变异系数:3.6%-5.2%;板间变异系数:5.7%-7.3%
回收率93%-109%
平均回收率105%
板式96孔板,可拆
保存条件2-8℃保存。已拆开:标准品-20℃保存,其它4℃。
运输条件2-8℃冰袋运输
检测原理本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人sTNFRI抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体,经过孵育,样本中存在的sTNFRI与固相抗体和检测抗体结合。洗涤去除未结合的物质后,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中sTNFRI的浓度成正比。加入终止液终止反应,在450nm波长(参考波长570 - 630nm)测定吸光度值。

分子信息

概述人 TNFRSF1A, TNFR1, CD120a 靶点信息

TNFRSF1A 分子靶点信息概述

  • 分子名:TNFRSF1A, TNF receptor superfamily member 1A
  • 基因家族:CD molecules; Tumor necrosis factor receptor superfamily
  • 别名:TNF-R; TNFAR; TNFR60; TNF-R-I; CD120a; TNF-R55
  • 曾用名:TNFR1
  • 全称:tumor necrosis factor receptor superfamily, member 1A

TNFRSF1A 分子靶点综述

肿瘤坏死因子受体1(TNFRI),又名肿瘤坏死因子受体超家族成员1A(TNFRSF1A)和CD120a,是肿瘤坏死因子受体超家族的一员。它能激活转录因子NF-κB、介导细胞凋亡和调控炎症。TNFRI基因突变与多发性硬化症风险增加有关。精神分裂症和双相情感障碍患者血清中的TNFRI水平是升高的,且高水平的TNFRI与更严重的精神病症状有关。

人 Human TNFRSF1A 分子靶点信息

  • 分子名:TNFRSF1A, TNF receptor superfamily member 1A
  • 别称:
    • CD120a
    • FPF
    • MGC19588
    • MS5
    • p55
    • p55-R
    • p60
    • TBP1
    • TNF-R
    • TNF-R-I
    • TNF-R1
    • TNF-R55
    • TNF-RI
    • TNFAR
    • TNFR-I
    • TNFR1
    • TNFR1-d2
    • TNFR55
    • TNFR60
    • tumor necrosis factor binding protein 1
    • tumor necrosis factor receptor 1
    • tumor necrosis factor receptor 1A isoform beta
    • tumor necrosis factor receptor superfamily member 1A
    • tumor necrosis factor receptor superfamily, member 1A
    • tumor necrosis factor receptor type 1
    • tumor necrosis factor receptor type I
    • tumor necrosis factor-alpha receptor
  • 基因序列:NCBI_Gene: 7132
  • 蛋白序列:UniProtKB: P19438

人 Human TNFRSF1A靶点分子功能(预测)

Enables tumor necrosis factor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of nitrogen compound metabolic process; and tumor necrosis factor-mediated signaling pathway. Located in Golgi membrane; extracellular space; and membrane raft. Part of receptor complex. Implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Biomarker of several diseases, including acquired immunodeficiency syndrome; autoimmune disease (multiple); female reproductive organ cancer (multiple); kidney disease (multiple); and lung disease (multiple).

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