Human sTNF RI/TNFRSF1A ELISA Kit检测试剂盒(酶联免疫吸附法)
¥1,600.00 – ¥2,650.00
在售SKU:70-EK1109-48, 70-EK1109-96, EK1109, 人, 可溶性, 肿瘤, 坏死, 因子, 受体, 1
- 分子靶点:TNFRSF1A
- 种属:人
- 样本类型:血清、血浆、细胞培养上清及其他生物学样本
- 检测样本体积:血清、血浆样本10μL
- 灵敏度:0.08pg/mL
- 检测范围:7.81-500pg/mL
- 回收率:93%-109%
ELISA试剂盒详细信息
商品名 | 人可溶性肿瘤坏死因子受体1酶联免疫检测试剂盒 |
---|---|
种属 | 人 |
靶点 | TNFRSF1A |
检测方法 | 双抗体夹心法 |
检测样本类型 | 血清、血浆、细胞培养上清及其他生物学样本 |
检测样本体积 | 血清、血浆样本10μL |
灵敏度 | 0.08pg/mL |
线性范围 | 7.81-500pg/mL |
精密度 | 板内变异系数:3.6%-5.2%;板间变异系数:5.7%-7.3% |
回收率 | 93%-109% |
平均回收率 | 105% |
板式 | 96孔板,可拆 |
保存条件 | 2-8℃保存。已拆开:标准品-20℃保存,其它4℃。 |
运输条件 | 2-8℃冰袋运输 |
检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人sTNFRI抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体,经过孵育,样本中存在的sTNFRI与固相抗体和检测抗体结合。洗涤去除未结合的物质后,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中sTNFRI的浓度成正比。加入终止液终止反应,在450nm波长(参考波长570 - 630nm)测定吸光度值。 |
分子信息
TNFRSF1A 分子靶点信息概述
- 分子名:TNFRSF1A, TNF receptor superfamily member 1A
- 基因家族:CD molecules; Tumor necrosis factor receptor superfamily
- 别名:TNF-R; TNFAR; TNFR60; TNF-R-I; CD120a; TNF-R55
- 曾用名:TNFR1
- 全称:tumor necrosis factor receptor superfamily, member 1A
TNFRSF1A 分子靶点综述
肿瘤坏死因子受体1(TNFRI),又名肿瘤坏死因子受体超家族成员1A(TNFRSF1A)和CD120a,是肿瘤坏死因子受体超家族的一员。它能激活转录因子NF-κB、介导细胞凋亡和调控炎症。TNFRI基因突变与多发性硬化症风险增加有关。精神分裂症和双相情感障碍患者血清中的TNFRI水平是升高的,且高水平的TNFRI与更严重的精神病症状有关。
人 Human TNFRSF1A 分子靶点信息
- 分子名:TNFRSF1A, TNF receptor superfamily member 1A
- 别称:
- CD120a
- FPF
- MGC19588
- MS5
- p55
- p55-R
- p60
- TBP1
- TNF-R
- TNF-R-I
- TNF-R1
- TNF-R55
- TNF-RI
- TNFAR
- TNFR-I
- TNFR1
- TNFR1-d2
- TNFR55
- TNFR60
- tumor necrosis factor binding protein 1
- tumor necrosis factor receptor 1
- tumor necrosis factor receptor 1A isoform beta
- tumor necrosis factor receptor superfamily member 1A
- tumor necrosis factor receptor superfamily, member 1A
- tumor necrosis factor receptor type 1
- tumor necrosis factor receptor type I
- tumor necrosis factor-alpha receptor
- 基因序列:NCBI_Gene: 7132
- 蛋白序列:UniProtKB: P19438
人 Human TNFRSF1A靶点分子功能(预测)
Enables tumor necrosis factor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of nitrogen compound metabolic process; and tumor necrosis factor-mediated signaling pathway. Located in Golgi membrane; extracellular space; and membrane raft. Part of receptor complex. Implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Biomarker of several diseases, including acquired immunodeficiency syndrome; autoimmune disease (multiple); female reproductive organ cancer (multiple); kidney disease (multiple); and lung disease (multiple).
引用文献统计
该产品被引用的文献总数为:2
- Screening of TNFR1 Binding Peptides from Deinagkistrodon acutus Venom through Phage Display
影响因子:5.075刊物:Toxins发表日期:2022/2/19 - Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (?)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice
影响因子:8.6刊物:Cell Chemical Biology发表日期:2023-10-31