TNFRSF1A 靶点信息

TNFRSF1A 分子靶点信息概述

  • 分子名：TNFRSF1A, TNF receptor superfamily member 1A
  • 基因家族：CD molecules; Tumor necrosis factor receptor superfamily
  • 别名：TNF-R; TNFAR; TNFR60; TNF-R-I; CD120a; TNF-R55
  • 曾用名：TNFR1
  • 全称：tumor necrosis factor receptor superfamily, member 1A

TNFRSF1A 分子靶点综述

肿瘤坏死因子受体1(TNFRI)，又名肿瘤坏死因子受体超家族成员1A(TNFRSF1A)和CD120a，是肿瘤坏死因子受体超家族的一员。它能激活转录因子NF-κB、介导细胞凋亡和调控炎症。TNFRI基因突变与多发性硬化症风险增加有关。精神分裂症和双相情感障碍患者血清中的TNFRI水平是升高的，且高水平的TNFRI与更严重的精神病症状有关。

TNFRSF1A, TNF receptor superfamily member 1A 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFRSF1A 分子靶点信息

  • 分子名：TNFRSF1A, TNF receptor superfamily member 1A
  • 别称：
    • CD120a
    • FPF
    • MGC19588
    • MS5
    • p55
    • p55-R
    • p60
    • TBP1
    • TNF-R
    • TNF-R-I
    • TNF-R1
    • TNF-R55
    • TNF-RI
    • TNFAR
    • TNFR-I
    • TNFR1
    • TNFR1-d2
    • TNFR55
    • TNFR60
    • tumor necrosis factor binding protein 1
    • tumor necrosis factor receptor 1
    • tumor necrosis factor receptor 1A isoform beta
    • tumor necrosis factor receptor superfamily member 1A
    • tumor necrosis factor receptor superfamily, member 1A
    • tumor necrosis factor receptor type 1
    • tumor necrosis factor receptor type I
    • tumor necrosis factor-alpha receptor
  • 基因序列：NCBI_Gene: 7132
  • 蛋白序列：UniProtKB: P19438

人 Human TNFRSF1A靶点分子功能（预测）

Enables tumor necrosis factor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of nitrogen compound metabolic process; and tumor necrosis factor-mediated signaling pathway. Located in Golgi membrane; extracellular space; and membrane raft. Part of receptor complex. Implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Biomarker of several diseases, including acquired immunodeficiency syndrome; autoimmune disease (multiple); female reproductive organ cancer (multiple); kidney disease (multiple); and lung disease (multiple).

小鼠 Mouse Tnfrsf1a 分子靶点信息

小鼠 Mouse Tnfrsf1a 靶点分子功能（预测）

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including negative regulation of cardiac muscle hypertrophy; negative regulation of extracellular matrix constituent secretion; and semi-lunar valve development. Acts upstream of or within several processes, including defense response to bacterium; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of tumor necrosis factor-mediated signaling pathway. Located in cell surface and membrane raft. Is expressed in several structures, including alimentary system; extraembryonic component; hemolymphoid system; reproductive system; and respiratory system. Used to study autosomal dominant familial periodic fever. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).

大鼠 Rat Tnfrsf1a 分子靶点信息

  • 分子名：Tnfrsf1a, TNF receptor superfamily member 1A
  • 别称：
    • MGC105478
    • p55
    • p60
    • TNF-R1
    • TNF-RI
    • TNFR-1
    • TNFR-I
    • Tnfr1
    • Tumor necrosis factor receptor
    • tumor necrosis factor receptor 1
    • tumor necrosis factor receptor superfamily member 1A
    • tumor necrosis factor receptor superfamily, member 1a
    • tumor necrosis factor receptor type I
  • 基因序列：NCBI_Gene: 25625
  • 蛋白序列：

大鼠 Rat Tnfrsf1a 靶点分子功能（预测）

Enables protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of apoptotic process; and regulation of cytokine production. Located in several cellular components, including cell surface; membrane raft; and mitochondrion. Part of protein-containing complex. Used to study ischemia (multiple); middle cerebral artery infarction; myocardial infarction; uveitis; and visual epilepsy. Biomarker of several diseases, including root resorption; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).

TNFRSF1A 分子产品列表

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