Human Pentraxin 3/TSG-14 Standard (人穿透素3/肿瘤坏死因子诱导基因14 标准品)

PTX3 分子靶点信息概述

• 分子名：PTX3, pentraxin 3
• 基因家族：Long pentraxins
• 别名：TSG-14
• 曾用名：TNFAIP5
• 全称：long pentraxin 3; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced protein 5; pentraxin-related gene, rapidly induced by IL-1 beta; pentraxin 3, long

PTX3 分子靶点综述

穿透素3(Pentraxin3)也称为肿瘤坏死因子诱导基因14(TSG-14)，是穿透素超家族成员，具有环状多聚体结构。多种类型的细胞，尤其是单核吞噬细胞、树突细胞、成纤维细胞和内皮细胞，对初次炎症信号(如toll样受体、TNF-α、IL-1β)产生应答后，可快速产生并释放Pentraxin3。Pentraxin3是急性期应答蛋白，其在正常情况下含量较低(在小鼠中约25ng/ml，在人类中小于2ng/ml)，而在内毒素性休克、败血症和其它炎症和感染条件下，急剧升高(诱导后6-8小时达到峰值)，含量可达200-800ng/ml，与疾病的严重程度相关。在这些情况下，Pentraxin3是先天免疫和炎症反应局部活化的快速判断标志。研究显示Pentraxin3具有双重作用：保护机体抵抗病原体和调控自身免疫。

人 Human PTX3 分子靶点信息

• 分子名：PTX3, pentraxin 3
• 别称：
  • long pentraxin 3
  • pentaxin-related gene, rapidly induced by il-1 beta
  • pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5
  • pentaxin-related protein PTX3
  • pentraxin 3, long
  • pentraxin-3
  • pentraxin-related gene, rapidly induced by IL-1 beta
  • pentraxin-related protein PTX3
  • TNF alpha-induced protein 5
  • TNFAIP5
  • TSG-14
  • tumor necrosis factor alpha-induced protein 5
  • tumor necrosis factor-inducible gene 14 protein
  • tumor necrosis factor-inducible protein TSG-14
  • tumor necrosis factor, alpha-induced protein 5
• 基因序列：NCBI_Gene: 5806
• 蛋白序列：UniProtKB: P26022

人 Human PTX3靶点分子功能（预测）

Enables complement component C1q complex binding activity; identical protein binding activity; and virion binding activity. Involved in innate immune response; modulation by host of viral process; and negative regulation of viral entry into host cell. Located in extracellular space. Implicated in cystic fibrosis and invasive aspergillosis. Biomarker of hepatitis C; invasive aspergillosis; pelvic inflammatory disease; pulmonary aspergilloma; and toxic shock syndrome.