IL9 靶点信息

IL9 分子靶点信息概述

  • 分子名：IL9, interleukin 9
  • 基因家族：Interleukins
  • 别名：IL-9; HP40; P40
  • 全称：p40 T-cell and mast cell growth factor; T-cell growth factor p40; p40 cytokine; homolog of mouse T cell and mast cell growth factor 40

IL9 分子靶点综述

白细胞介素9(IL-9)是一个分子量为14kDa的糖基化蛋白，包含10个参与二硫键连接的半胱氨酸残基。它是由T细胞特别是CD4+辅助性细胞产生的细胞因子，可调节多种造血细胞。该细胞因子刺激细胞增殖、阻止细胞凋亡。它是通过与IL-9受体结合起作用的，可激活不同的信号转导及激活(STAT)蛋白，从而参与多种生物过程。编码该细胞因子的基因已被确定为哮喘的候选基因。小鼠模型的哮喘遗传研究表明，这种细胞因子是支气管高反应发病机制的一个决定性因素。IL-9介导的自分泌环的存在暗示着一些恶性肿瘤如霍奇金病的存在。IL-9由李-斯二氏细胞、霍奇金淋巴瘤细胞和一些大型再生障碍性淋巴瘤细胞表达，而非霍奇金淋巴瘤和外周T细胞淋巴瘤不表达。

IL9, interleukin 9 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL9 分子靶点信息

  • 分子名：IL9, interleukin 9
  • 别称：
    • cytokine P40
    • homolog of mouse T cell and mast cell growth factor 40
    • HP40
    • IL-9
    • interleukin-9
    • P40
    • p40 cytokine
    • p40 T-cell and mast cell growth factor
    • T-cell growth factor p40
  • 基因序列：NCBI_Gene: 3578
  • 蛋白序列：UniProtKB: P15248

人 Human IL9靶点分子功能（预测）

Predicted to enable cytokine activity and interleukin-9 receptor binding activity. Predicted to be involved in positive regulation of interleukin-5 production. Predicted to act upstream of or within several processes, including B cell activation; regulation of cellular protein metabolic process; and regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in asthma and respiratory syncytial virus infectious disease. Biomarker of COVID-19; asthma; cystic fibrosis; lung disease (multiple); and rhinitis.

小鼠 Mouse Il9 分子靶点信息

小鼠 Mouse Il9 靶点分子功能（预测）

Enables cytokine activity. Involved in positive regulation of interleukin-5 production. Acts upstream of or within several processes, including B cell activation; regulation of cellular protein metabolic process; and regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Is expressed in gut; liver; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma and respiratory syncytial virus infectious disease. Orthologous to human IL9 (interleukin 9).

大鼠 Rat Il9 分子靶点信息

大鼠 Rat Il9 靶点分子功能（预测）

Enables cytokine activity and interleukin-9 receptor binding activity. Involved in positive regulation of cell growth. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in asthma and respiratory syncytial virus infectious disease. Orthologous to human IL9 (interleukin 9).

IL9 分子产品列表

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