EK113S

Human IL-13 Standard (人白细胞介素13 标准品)

¥180.00

  • 分子靶点:IL13, ALRH, BHR1
  • 种属:人 (Human)
  • 试剂盒:EK113
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK113S


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商品名

Human IL-13 Standard (人白细胞介素13 标准品)

组分

人IL-13 标准品

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

分子信息

概述人 IL13, ALRH, BHR1 靶点信息

IL13 分子靶点信息概述

  • 分子名:IL13, interleukin 13
  • 基因家族:Interleukins
  • 别名:P600; IL-13; ALRH; BHR1; MGC116786; MGC116788; MGC116789
  • 全称:allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma)

IL13 分子靶点综述

白细胞介素13(IL-13)位于染色体5q31上,与IL-4具有30%的同源性和相似的结构。IL-13由许多细胞类型分泌产生,尤其是2型辅助性T细胞(Th2)。与密切相关的IL-4相似,IL-13对免疫细胞也具有多种功能。虽然IL-13主要与气道疾病的诱导相关,但是它还具有消炎特性。IL-13可诱导造血细胞的变化,但是这些效果与IL-4相比可能不那么重要。IL-13专门诱导寄生感染的器官的生理变化。它也可诱导过敏性肺部疾病的许多特征,包括气道高反应性、杯状细胞增殖和黏液高分泌,这些都会导致气道阻塞。此外,IL-13抑制原代培养衍生的巨噬细胞中HIV-1的复制,可作为体内单核细胞和巨噬细胞中抑制HIV感染的候选细胞因子。

人 Human IL13 分子靶点信息

  • 分子名:IL13, interleukin 13
  • 别称:
    • allergic rhinitis
    • ALRH
    • BHR1
    • Bronchial hyperresponsiveness-1 (bronchial asthma)
    • IL-13
    • interleukin-13
    • MGC116786
    • MGC116788
    • MGC116789
    • P600
  • 基因序列:NCBI_Gene: 3596
  • 蛋白序列:UniProtKB: P35225

人 Human IL13靶点分子功能(预测)

Predicted to enable cytokine activity and interleukin-13 receptor binding activity. Involved in several processes, including negative regulation of complement-dependent cytotoxicity; negative regulation of endothelial cell apoptotic process; and positive regulation of interleukin-10 production. Located in extracellular region. Implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Biomarker of several diseases, including Plasmodium falciparum malaria; autoimmune disease (multiple); cystic fibrosis; lung disease (multiple); and scleroderma (multiple).

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  1. Alteration of Myeloid-Derived Suppressor Cells, Chronic Inflammatory Cytokines, and Exosomal miRNA Contribute to the Peritoneal Immune Disorder of Patients With Endometriosis 

  2. Elevated serum IL-13 level is associated with increased Treg cells in tumor microenvironment and disease progression of diffuse large B-cell lymphoma 

  3. Mesenchymal stromal cells pretreated with proinflammatory cytokines enhance skin wound healing via IL-6-dependent M2 polarization 

  4. Type 2 innate lymphoid cells participate in IL‑33‑stimulated Th2‑associated immune response in chronic obstructive pulmonary disease 

  5. Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma 

  6. Sputum basophils from allergic asthmatic patients do not express IL-7Rα that is essential for TSLP signalling 

  7. Regulation of CBL and ESR1 expression by microRNA-22‑3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma 

  8. ILC2 Cells Promote Th2 Cell Differentiation in AECOPD Through Activated Notch-GATA3 Signaling Pathway 

  9. ILC2s Induce Adaptive Th2-Type Immunity in Acute Exacerbation of Chronic Obstructive Pulmonary Disease 

  10. Interleukin 3-induced GITR promotes the activation of human basophils 

  11. Induction of the apoptosis, degranulation and IL-13 production of human basophils by butyrate and propionate via suppression of histone deacetylation 

  12. Effects of Sarcoptes scabiei Translationally Controlled Tumor Protein (TCTP) on Histamine Release and Degranulation of KU812 Cells 

  13. IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps 

  14. c-CBL/LCK/c-JUN/ETS1/CD28 axis restrains childhood asthma by suppressing Th2 differentiation 

  15. Targeting mitochondrial dysfunction in atopic dermatitis with trilinolein: a triacylglycerol from the medicinal plant Cannabis fructus 

  16. CLDN1 silencing suppresses the proliferation and migration of airway smooth muscle cells by modulating MMP14 

  17. The enrichment of Arg1+ILC2s and ILCregs facilitates the progression of endometriosis: A preliminary study 

  18. Silibinin attenuated pseudo-allergic reactions and mast cell degranulation via PLCγ and PI3K/Akt signaling pathway 

  19. 腹腔上清液

    Alteration of Myeloid-Derived Suppressor Cells, Chronic Inflammatory Cytokines, and Exosomal miRNA Contribute to the Peritoneal Immune Disorder of Patients With Endometriosis 

  20. Activation of Tgf-Β1/Α-Sma/Col I Profibrotic Pathway in Fibroblasts by Galectin-3 Contributes to Atrial Fibrosis in Experimental Models and Patients 

  21. Induction of the Apoptosis, Degranulation and Il-13 Production of Human Basophils by Butyrate and Propionate Via Suppression of Histone Deacetylation