Human IGF-1 Standard (人胰岛素样生长因子1 标准品)

IGF1 分子靶点信息概述

• 分子名：IGF1, insulin like growth factor 1
• 基因家族：Neuropeptides
• 别名：IGF1A; IGFI; IGF-I; IGF
• 全称：somatomedin C; insulin-like growth factor 1 (somatomedin C)

IGF1 分子靶点综述

胰岛素样生长因子1(IGF-1)，也称为生长调节素C，是一个在分子结构上类似于胰岛素的激素。IGF-1主要由肝脏产生，作为内分泌激素。同样地，靶组织亦能旁分泌/自分泌产生IGF-1。IGF-1是AKT信号转导途径中的一种有效天然激活剂、细胞生长和增殖的刺激子、细胞程序性死亡的有效抑制子。IGF-1最少可结合两种细胞表面受体：IGF-1受体(IGF1R)和胰岛素受体。IGF-1的产生受生长激素刺激，受营养不良、生长激素不敏感、缺少生长激素受体或者生长激素受体(SHP2和STAT5B)下游信号通路发生故障等方面所抑制。IGF-1在儿童生长过程中起重要作用，继而在成人合成代谢中有影响，且与老年化、神经病变、癌症以及中风相关。

人 Human IGF1 分子靶点信息

• 分子名：IGF1, insulin like growth factor 1
• 别称：
  • IGF
  • IGF-I
  • IGF-IA
  • IGF-IB
  • IGF1A
  • IGFI
  • insulin-like growth factor 1
  • insulin-like growth factor 1 (somatomedin C)
  • insulin-like growth factor I
  • insulin-like growth factor IA
  • insulin-like growth factor IB
  • mechano growth factor
  • MGF
  • somatomedin-C
• 基因序列：NCBI_Gene: 3479
• 蛋白序列：UniProtKB: P05019

人 Human IGF1靶点分子功能（预测）

Enables signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within cell activation. Located in extracellular space. Part of alphav-beta3 integrin-IGF-1-IGF1R complex and insulin-like growth factor ternary complex. Implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Biomarker of several diseases, including Henoch-Schoenlein purpura; artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); and eye disease (multiple).