EK1182S

Human ErbB2/HER2/CD340 Standard (人表皮生长因子受体2 (HER2) 标准品)

¥280.00

分子靶点：ERBB2, HER2, CD340, NEU
种属：人 (Human)
试剂盒：EK1182
保存：短期4℃保存，长期-20℃保存
运输条件：4℃蓝冰运输

在售SKU:70-EK1182S

描述

文章目录[隐藏]

本产品只包含标准品试剂，如需购买试剂盒请点击下图
分子信息
ERBB2 分子靶点信息概述
ERBB2 分子靶点综述
- 人 Human ERBB2 分子靶点信息
- 人 Human ERBB2靶点分子功能（预测）

本产品只包含标准品试剂，如需购买试剂盒请点击下图

快速查看
- 快速查看
- EK1182
- ELISA试剂盒
- Human ErbB2/HER2/CD340 ELISA Kit检测试剂盒（酶联免疫吸附法）
- ¥1,600.00 – ¥2,650.00

商品名	Human ErbB2/HER2/CD340 Standard (人表皮生长因子受体2 (HER2) 标准品)
组分	人ErbB2/HER2/CD340标准品
检测方法	双抗夹心法
样本类型	血清，血浆，细胞培养上清及其他生物学样本
板式	管
保存	短期4℃，长期-20℃保存
运输条件	4℃蓝冰运输

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人ErbB2抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、检测样本和辣根过氧化物酶标记的检测抗体，经过孵育，样本中存在的ErbB2与固相抗体和检测抗体结合。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中ErbB2的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human ErbB2/HER2/CD340 ELISA Kit (人表皮生长因子受体2 (HER2) ELISA试剂盒) - 标准曲线 — 标准曲线

分子信息

概述人 ERBB2, HER2, CD340, NEU 靶点信息

ERBB2 分子靶点信息概述

分子名：ERBB2, erb-b2 receptor tyrosine kinase 2
基因家族：CD molecules; Minor histocompatibility antigens; Erb-b2 receptor tyrosine kinases; MicroRNA protein coding host genes
别名：NEU; HER-2; CD340; HER2
曾用名：NGL
全称：neuro/glioblastoma derived oncogene homolog; human epidermal growth factor receptor 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

ERBB2 分子靶点综述

ErbB2在人类中由ERBB2基因编码，通常也称之为原癌基因人类表皮生长因子受体2(HER2)或CD340。HER2由胞外配体结合域、跨膜结构域和胞内结构域3部分组成，这些结构域可以和大量信号分子相互作用，体现出配体依赖和非配体依赖性活性。扩增或过表达该致癌基因对某些不良类型的乳腺癌发展有重要作用。近几年来，该蛋白已成为近30%乳腺癌患者生物治疗的一个重要靶点。

人 Human ERBB2 分子靶点信息

分子名：ERBB2, erb-b2 receptor tyrosine kinase 2
别称：
- c-erb B2/neu protein
- CD340
- HER-2
- HER-2/neu
- HER2
- herstatin
- human epidermal growth factor receptor 2
- metastatic lymph node gene 19 protein
- MLN 19
- NEU
- neuro/glioblastoma derived oncogene homolog
- neuroblastoma/glioblastoma derived oncogene homolog
- NGL
- p185erbB2
- proto-oncogene c-ErbB-2
- proto-oncogene Neu
- receptor tyrosine-protein kinase erbB-2
- TKR1
- tyrosine kinase-type cell surface receptor HER2
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
- v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- VSCN2
基因序列：NCBI_Gene: 2064
蛋白序列：UniProtKB: P04626

人 Human ERBB2靶点分子功能（预测）

Enables several functions, including ErbB-3 class receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Contributes to growth factor binding activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; protein phosphorylation; and regulation of MAPK cascade. Acts upstream of or within cell surface receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; cytosol; and endosome membrane. Part of ERBB3:ERBB2 complex. Implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Biomarker of several diseases, including carcinoma (multiple); ductal carcinoma in situ; invasive lobular carcinoma; pre-eclampsia (multiple); and urinary system cancer (multiple).