Human Ephrin-A1/EFNA1 Standard (人Ephrin-A1 标准品)

EFNA1 分子靶点信息概述

• 分子名：EFNA1, ephrin A1
• 基因家族：Ephrins
• 别名：LERK1; ECKLG; GMAN
• 曾用名：TNFAIP4; EPLG1
• 全称：EPH-related receptor tyrosine kinase ligand 1; Tumor necrosis factor alpha-induced protein 4; gastric cancer metastasis associated long noncoding RNA; ephrin-A1

EFNA1 分子靶点综述

Ephrin-A1，又名EFNA1，在人类中由EFNA1基因编码，该基因编码Eph家族成员。ephrins和Eph相关受体组成了最大的受体酪氨酸激酶亚家族，参与调节神经和造血系统的发展。根据它们的结构和序列关系，ephrins可分为ephrin-A(EFNA)类和ephrin-B(EFNB)类。Ephrin-A配体结合EphA受体，通过糖基磷脂酰肌醇(GPI)连接锚定到质膜上。而ephrin-B配体结合EphB受体，通过跨膜结构域锚定到质膜上。Ephrin-A1及它的其中之一受体EphA2在异种移植的内皮细胞和肿瘤细胞中表达，在某种程度上可通过影响肿瘤新血管形成，从而在人类癌症中发挥作用。

人 Human EFNA1 分子靶点信息

• 分子名：EFNA1, ephrin A1
• 别称：
  • B61
  • ECKLG
  • EFL1
  • eph-related receptor tyrosine kinase ligand 1
  • ephrin-A1
  • EPLG1
  • gastric cancer metastasis associated long noncoding RNA
  • GMAN
  • immediate early response protein B61
  • LERK-1
  • LERK1
  • ligand of eph-related kinase 1
  • TNF alpha-induced protein 4
  • TNFAIP4
  • tumor necrosis factor alpha-induced protein 4
  • tumor necrosis factor, alpha-induced protein 4
• 基因序列：NCBI_Gene: 1942
• 蛋白序列：UniProtKB: P20827

人 Human EFNA1靶点分子功能（预测）

Enables ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; protein stabilization; and regulation of protein metabolic process. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Predicted to be anchored component of plasma membrane.