EK1265S

Human CXCL3/GRO-γ Standard (人趋化因子 (C-X-C基序) 配体3 (CXCL3/GRO-γ) 标准品)

¥280.00

  • 分子靶点:CXCL3, MIP-2b, GRO3, GROg
  • 种属:人 (Human)
  • 试剂盒:EK1265
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK1265S


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商品名

Human CXCL3/GRO-γ Standard (人趋化因子 (C-X-C基序) 配体3 (CXCL3/GRO-γ) 标准品)

组分

人CXCL3/GRO-γ冻干标准品

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

分子信息

概述人 CXCL3, MIP-2b, GRO3, GROg 靶点信息

CXCL3 分子靶点信息概述

  • 分子名:CXCL3, C-X-C motif chemokine ligand 3
  • 基因家族:Chemokine ligands
  • 别名:SCYB3; GROg; MIP-2b; CINC-2b
  • 曾用名:GRO3
  • 全称:GRO3 oncogene; chemokine (C-X-C motif) ligand 3

CXCL3 分子靶点综述

CXCL1、CXCL2和CXCL3,分别称为GRO alpha, GRO beta (MIP-2 alpha) 和GRO gamma (MIP-2 beta),是趋化因子的CXC亚家族成员。成熟的CXCL1/2/3蛋白与B型IL-8受体高度亲和结合,是有效的中性粒细胞吸引剂和活化剂。趋化因子主要作用于白细胞,调节其运输。一般来说,趋化因子α家族成员优先趋化并激活中性粒细胞。重组人生长调节致癌基因γ(GRO-γ)是一种7.9kDa蛋白质,由73个氨基酸组成,包括与CXCR1或CXCR2结合的CXC趋化因子家族共有的“ELR”基序。成熟的人CXCL3 (aa 35-107)与小鼠和大鼠CXCL3的氨基酸序列同源性分别为70%和74%。CXCL3通过与CXCR2受体的相互作用,在单核细胞迁移和粘附中起着关键作用。

人 Human CXCL3 分子靶点信息

  • 分子名:CXCL3, C-X-C motif chemokine ligand 3
  • 别称:
    • C-X-C motif chemokine 3
    • chemokine (C-X-C motif) ligand 3
    • CINC-2b
    • GRO-gamma
    • GRO-gamma(1-73)
    • GRO3
    • GRO3 oncogene
    • GROg
    • growth-regulated protein gamma
    • macrophage inflammatory protein 2-beta
    • melanoma growth stimulatory activity gamma
    • MGSA gamma
    • MIP-2b
    • MIP2-beta
    • MIP2B
    • SCYB3
  • 基因序列:NCBI_Gene: 2921
  • 蛋白序列:UniProtKB: P19876

人 Human CXCL3靶点分子功能(预测)

Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Located in extracellular space.

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引用文献


  1. Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet’s disease 

  2. HPV11E7 inhibits IMQ-induced chemokine and colony-stimulating factor production in keratinocytes 

  3. Interleukin-26 Expression in Inflammatory Bowel Disease and Its Immunoregulatory Effects on Macrophages 

  4. Cancer-associated adipocytes promote the invasion and metastasis in breast cancer through LIF/CXCLs positive feedback loop 

  5. Deciphering m6A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy 

  6. Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D 

  7. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A 

  8. Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis 

  9. Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions 

  10. An inflammatory checkpoint generated by IL1RN splicing offers therapeutic opportunity for KRAS mutant intrahepatic cholangiocarcinoma 

  11. CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway 

  12. 细胞培养上清

    Dedifferentiation-associated inflammatory factors of long-term expanded human hepatocytes exacerbate their elimination by macrophages during liver engraftment