EK1265
Human CXCL3/GRO-γ ELISA Kit检测试剂盒(酶联免疫吸附法)
¥1,600.00 – ¥2,650.00
在售SKU:70-EK1265-48, 70-EK1265-96, EK1265
- 分子靶点:CXCL3
- 种属:人
- 样本类型:血清、血浆、细胞培养上清及其他生物学样本
- 检测样本体积:血清、血浆样本10μL
- 灵敏度:0.24pg/mL
- 检测范围:1.56-100pg/mL
- 回收率:86%-105%
ELISA试剂盒详细信息
商品名 | 人趋化因子(C-X-C基序)配体3酶联免疫检测试剂盒 |
---|---|
种属 | 人 |
靶点 | CXCL3 |
检测方法 | 双抗体夹心法 |
检测样本类型 | 血清、血浆、细胞培养上清及其他生物学样本 |
检测样本体积 | 血清、血浆样本10μL |
灵敏度 | 0.24pg/mL |
线性范围 | 1.56-100pg/mL |
精密度 | 板内变异系数:2.6%-5.5%;板间变异系数:11.5%-5.9% |
回收率 | 86%-105% |
平均回收率 | 95% |
板式 | 96孔板,可拆 |
保存条件 | 2-8℃保存。已拆开:标准品-20℃保存,其它4℃。 |
运输条件 | 2-8℃冰袋运输 |
检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性检测抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本,经过孵育,样本中存在的待测物质与固相抗体结合。洗涤去除未结合的物质后,加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中CXCL3的浓度成正比。加入终止液终止反应,在450nm波长(参考波长570 - 630nm)测定吸光度值。 |
分子信息
概述人 CXCL3, MIP-2b, GRO3, GROg 靶点信息
CXCL3 分子靶点信息概述
- 分子名:CXCL3, C-X-C motif chemokine ligand 3
- 基因家族:Chemokine ligands
- 别名:SCYB3; GROg; MIP-2b; CINC-2b
- 曾用名:GRO3
- 全称:GRO3 oncogene; chemokine (C-X-C motif) ligand 3
CXCL3 分子靶点综述
CXCL1、CXCL2和CXCL3,分别称为GRO alpha, GRO beta (MIP-2 alpha) 和GRO gamma (MIP-2 beta),是趋化因子的CXC亚家族成员。成熟的CXCL1/2/3蛋白与B型IL-8受体高度亲和结合,是有效的中性粒细胞吸引剂和活化剂。趋化因子主要作用于白细胞,调节其运输。一般来说,趋化因子α家族成员优先趋化并激活中性粒细胞。重组人生长调节致癌基因γ(GRO-γ)是一种7.9kDa蛋白质,由73个氨基酸组成,包括与CXCR1或CXCR2结合的CXC趋化因子家族共有的“ELR”基序。成熟的人CXCL3 (aa 35-107)与小鼠和大鼠CXCL3的氨基酸序列同源性分别为70%和74%。CXCL3通过与CXCR2受体的相互作用,在单核细胞迁移和粘附中起着关键作用。
人 Human CXCL3 分子靶点信息
- 分子名:CXCL3, C-X-C motif chemokine ligand 3
- 别称:
- C-X-C motif chemokine 3
- chemokine (C-X-C motif) ligand 3
- CINC-2b
- GRO-gamma
- GRO-gamma(1-73)
- GRO3
- GRO3 oncogene
- GROg
- growth-regulated protein gamma
- macrophage inflammatory protein 2-beta
- melanoma growth stimulatory activity gamma
- MGSA gamma
- MIP-2b
- MIP2-beta
- MIP2B
- SCYB3
- 基因序列:NCBI_Gene: 2921
- 蛋白序列:UniProtKB: P19876
人 Human CXCL3靶点分子功能(预测)
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Located in extracellular space.
引用文献统计
该产品被引用的文献总数为:12
- Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet’s disease
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影响因子:5.058刊物:Frontiers in Medicine发表日期:2022/4/6 - Cancer-associated adipocytes promote the invasion and metastasis in breast cancer through LIF/CXCLs positive feedback loop
影响因子:10.75刊物:International Journal of Biological Sciences发表日期:2022/1/16 - Deciphering m6A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy
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影响因子:2.1刊物:Open Medicine发表日期:2023-11-15 - Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis
影响因子:33.5刊物:Cell Discovery发表日期:2023-10-10 - Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions
影响因子:5.9刊物:Communications Biology发表日期:2023-09-05 - An inflammatory checkpoint generated by IL1RN splicing offers therapeutic opportunity for KRAS mutant intrahepatic cholangiocarcinoma
影响因子:28.2刊物:Cancer Discovery发表日期:2023-07-24 - CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway
影响因子:5.5刊物:Journal of Molecular Cell Biology发表日期:2023-04-18 - Dedifferentiation-associated inflammatory factors of long-term expanded human hepatocytes exacerbate their elimination by macrophages during liver engraftment
影响因子:17.298刊物:Hepatology. 2022 Mar 1.