Human CCL26/Eotaxin-3 Standard (人趋化因子CC配体26/嗜酸性粒细胞趋化因子-3 标准品)

CCL26 分子靶点信息概述

• 分子名：CCL26, C-C motif chemokine ligand 26
• 基因家族：Chemokine ligands
• 别名：MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1
• 曾用名：SCYA26
• 全称：macrophage inflammatory protein 4-alpha; small inducible cytokine A26; CC chemokine IMAC; chemokine N1; thymic stroma chemokine-1; eotaxin-3; small inducible cytokine subfamily A (Cys-Cys), member 26; chemokine (C-C motif) ligand 26

CCL26 分子靶点综述

趋化因子CC配体26(CCL26)是属于CC趋化因子家族的小分子量细胞因子，也称为嗜酸细胞活化趋化因子3(Eotaxin-3)、巨噬细胞炎性蛋白4α(MIP-4α)、胸腺基质趋化因子1(TSC-1)和IMAC。它表达于多种组织，包括心脏、肺和卵巢，以及IL-4刺激的内皮细胞。Eotaxin-3通过与细胞表面的趋化因子受体CCR3结合，对嗜酸性粒细胞和嗜碱性粒细胞产生趋化作用。Eotaxin-3和Eotaxin-1、Eotaxin-2一起选择性地活化CCR3。Eotaxin-3-CCR3的相互作用在过敏性疾病如特异反应性皮炎和支气管哮喘中具有重要作用。

人 Human CCL26 分子靶点信息

• 分子名：CCL26, C-C motif chemokine ligand 26
• 别称：
  • C-C motif chemokine 26
  • CC chemokine IMAC
  • chemokine (C-C motif) ligand 26
  • chemokine N1
  • eotaxin-3
  • IMAC
  • macrophage inflammatory protein 4-alpha
  • MGC126714
  • MIP-4-alpha
  • MIP-4a
  • MIP-4alpha
  • SCYA26
  • small inducible cytokine A26
  • small inducible cytokine subfamily A (Cys-Cys), member 26
  • small-inducible cytokine A26
  • thymic stroma chemokine-1
  • TSC-1
• 基因序列：NCBI_Gene: 10344
• 蛋白序列：UniProtKB: Q9Y258

人 Human CCL26靶点分子功能（预测）

Enables CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Located in extracellular space. Implicated in asthma; eosinophilic esophagitis; and rhinitis. Biomarker of several diseases, including Churg-Strauss syndrome; dermatitis (multiple); eosinophilic esophagitis; eosinophilic gastroenteritis; and rhinitis (multiple).