Anti-Rat Foxp3, PE (Clone: FJK-16s) 检测试剂

FOXP3 分子靶点信息概述

• 分子名：FOXP3, forkhead box P3
• 基因家族：Forkhead boxes
• 别名：JM2; XPID; AIID; PIDX; DIETER; SCURFIN
• 曾用名：IPEX
• 全称：immune dysregulation, polyendocrinopathy, enteropathy, X-linked

FOXP3 分子靶点综述

FoxP3蛋白是转录因子叉头家族的成员之一，表达于调节性T细胞(Regulatory T Cells, Treg)，其发育和功能受到叉头蛋白的影响。T细胞中FoxP3的异常表达会抑制其活性和细胞因子分泌。

大鼠 Rat Foxp3 分子靶点信息

• 分子名：Foxp3, forkhead box P3
• 别称：
  • forkhead box protein P3
  • LOC317382
  • RGD1562112
  • similar to scurfin
• 基因序列：NCBI_Gene: 317382
• 蛋白序列：
  • UniprotKB: D3ZKI1
  • UniprotKB: D4Q8I2
  • UniprotKB: D4Q8I3

大鼠 Rat Foxp3 靶点分子功能（预测）

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including establishment of endothelial blood-brain barrier; negative regulation of defense response to virus; and response to rapamycin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Used to study intrahepatic cholangiocarcinoma. Biomarker of Korean hemorrhagic fever; asthma; bronchiolitis obliterans; hypertension; and hypothyroidism. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).